Chen, S.-L.; Hu, S.-W.; Lin, Y.-Y.; Liao, W.-L.; Yang, J.-J. Boehmeria Nivea Extract (BNE-RRC) Reverses Epithelial-Mesenchymal Transition and Inhibits Anchorage-Independent Growth in Tumor Cells. International Journal of Molecular Sciences 2024, 25, 9572, doi:10.3390/ijms25179572.
Chen, S.-L.; Hu, S.-W.; Lin, Y.-Y.; Liao, W.-L.; Yang, J.-J. Boehmeria Nivea Extract (BNE-RRC) Reverses Epithelial-Mesenchymal Transition and Inhibits Anchorage-Independent Growth in Tumor Cells. International Journal of Molecular Sciences 2024, 25, 9572, doi:10.3390/ijms25179572.
Chen, S.-L.; Hu, S.-W.; Lin, Y.-Y.; Liao, W.-L.; Yang, J.-J. Boehmeria Nivea Extract (BNE-RRC) Reverses Epithelial-Mesenchymal Transition and Inhibits Anchorage-Independent Growth in Tumor Cells. International Journal of Molecular Sciences 2024, 25, 9572, doi:10.3390/ijms25179572.
Chen, S.-L.; Hu, S.-W.; Lin, Y.-Y.; Liao, W.-L.; Yang, J.-J. Boehmeria Nivea Extract (BNE-RRC) Reverses Epithelial-Mesenchymal Transition and Inhibits Anchorage-Independent Growth in Tumor Cells. International Journal of Molecular Sciences 2024, 25, 9572, doi:10.3390/ijms25179572.
Abstract
The Epithelial-Mesenchymal-Transition (EMT) phenotype, identified as a significant clinical indicator in cancer, manifests as a biological process where cells transition from epithelial to mesenchymal characteristics. Physiologically, EMT plays a crucial role in tissue remodeling, promoting healing, repair, and responding to various tissue damages. This study investigates the impact of BNE-RRC on oral cancer cells (KB) and reveals its significant effects on cancer cell growth, migration, invasion, and EMT. BNE-RRC induces the epithelial-like morphology in KB cells, effectively reversing EMT to Mesenchymal-Epithelial Transition (MET). Extraordinarily, sustained culture of cancer cells with BNE-RRC for 14 days maintains an epithelial status even after treatment withdrawal, suggesting BNE-RRC as a potential therapeutic agent for cancer. These findings highligh the promise of BNE-RRC as a comprehensive therapeutic agent in cancer treatment by inhibiting cancer cell growth, migration, and invasion, while also orchestrating a reversal of the EMT process. The study proposes that BNE-RRC could be effective agent for cancer treatment.
Keywords
Boehmeria Nivea Extract (BNE-RRC); Epithelial-Mesenchymal Transition (EMT); Mesenchymal-Epithelial Transition (MET); Anchorage-Independent Growth; Telomerase Activity, and Reversal of EMT
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
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