Universal mRNA-based HIV Vaccine for Acute and Latent Infections

Sarfaraz K. Niazi; Matthias Magoola

doi:10.20944/preprints202403.1035.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 15 March 2024 / Approved: 18 March 2024 / Online: 18 March 2024 (11:24:43 CET)

Human Immunodeficiency Virus (HIV) infection and its latent recurrent infection make vaccine development a significant challenge for traditional vaccines; however, the mRNA delivery of multiepitope antigens capable of creating antibodies against the surface proteins of HIV-1 and HIV-2 along with their respective Nef proteins, responsible for the latent infection can bring a most effective, as well as affordable solution to the unresolved epidemics of HIV. In this paper, we present the complete design of a multiepitope vaccine to prevent acute infections and inactivate Nef proteins that block the MHC-1 and MHC-2 pathways to hide the virus for later reinfection.

HIV-1 1; HIV-2 2; surface proteins 3; Nef proteins 4; mRNA delivery 5; Universal vaccine.

Medicine and Pharmacology, Immunology and Allergy

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Universal mRNA-based HIV Vaccine for Acute and Latent Infections

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