Version 1
: Received: 12 March 2024 / Approved: 13 March 2024 / Online: 13 March 2024 (09:48:46 CET)
How to cite:
Shellard, E.M.; Rane, S.S.; Eyre, S.; Warren, R.B. Functional genomics and insights into the pathogenesis and treatment of psoriasis.. Preprints2024, 2024030763. https://doi.org/10.20944/preprints202403.0763.v1
Shellard, E.M.; Rane, S.S.; Eyre, S.; Warren, R.B. Functional genomics and insights into the pathogenesis and treatment of psoriasis.. Preprints 2024, 2024030763. https://doi.org/10.20944/preprints202403.0763.v1
Shellard, E.M.; Rane, S.S.; Eyre, S.; Warren, R.B. Functional genomics and insights into the pathogenesis and treatment of psoriasis.. Preprints2024, 2024030763. https://doi.org/10.20944/preprints202403.0763.v1
APA Style
Shellard, E.M., Rane, S.S., Eyre, S., & Warren, R.B. (2024). Functional genomics and insights into the pathogenesis and treatment of psoriasis.. Preprints. https://doi.org/10.20944/preprints202403.0763.v1
Chicago/Turabian Style
Shellard, E.M., Stephen Eyre and Richard B Warren. 2024 "Functional genomics and insights into the pathogenesis and treatment of psoriasis." Preprints. https://doi.org/10.20944/preprints202403.0763.v1
Abstract
Psoriasis is a lifelong, systemic, immune mediated inflammatory skin condition, affecting 1-3% of the world’s population, with an impact on quality of life similar to diseases like cancer or diabetes. Genetics are the single largest risk factor in psoriasis, with GWAS studies showing that many psoriasis risk genes lie along the IL23/Th17 axis. Potential psoriasis risk genes determined through GWAS can be annotated and characterised using functional genomics, allowing the identification of novel drug targets and the repurposing of existing drugs. The pathogenesis of psoriasis is complex and focusing on the IL23/Th17 axis can provide insight into key cell types, cytokines and intracellular signaling pathways involved. Examination of currently available biological treatments, time to relapse post drug withdrawal and rates of drug primary/secondary drug failure show the need for greater understanding of the underlying genetic mechanisms of psoriasis and how they can impact treatment. This could allow for patient stratification towards the treatment most likely reduce dis-ease burden for the longest period possible.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
