Fiuza, S.; Marques, T.; Padin, I.; Carvalho, M.T.; Veiga, N.; Fernandes, J.C.H.; Fernandes, G.V.O.; Couto, P. Histological, Clinical Assessment, and Treatment of a Permanent Filler Complication in the Upper Lip: A Case Report with 16-Year Follow-Up. Cosmetics2024, 11, 50.
Fiuza, S.; Marques, T.; Padin, I.; Carvalho, M.T.; Veiga, N.; Fernandes, J.C.H.; Fernandes, G.V.O.; Couto, P. Histological, Clinical Assessment, and Treatment of a Permanent Filler Complication in the Upper Lip: A Case Report with 16-Year Follow-Up. Cosmetics 2024, 11, 50.
Fiuza, S.; Marques, T.; Padin, I.; Carvalho, M.T.; Veiga, N.; Fernandes, J.C.H.; Fernandes, G.V.O.; Couto, P. Histological, Clinical Assessment, and Treatment of a Permanent Filler Complication in the Upper Lip: A Case Report with 16-Year Follow-Up. Cosmetics2024, 11, 50.
Fiuza, S.; Marques, T.; Padin, I.; Carvalho, M.T.; Veiga, N.; Fernandes, J.C.H.; Fernandes, G.V.O.; Couto, P. Histological, Clinical Assessment, and Treatment of a Permanent Filler Complication in the Upper Lip: A Case Report with 16-Year Follow-Up. Cosmetics 2024, 11, 50.
Abstract
There is a considerable increase in the use of substances and medical procedures aimed at changing the esthetics of the face, particularly the appearance of the lips. Permanent fillers such as polydimethylsiloxane, also called liquid silicone, are widely used, but their application for facial esthetics is currently obsolete. However, the long-term complications remain a reality, as they can occur decades after the application. Thus, the goal of this case report was to present a complication after 16 years of treatment using liquid silicone. This case report involved a 52-year-old male with a complication of bilateral permanent filler in the upper lip performed 16 years ago, its surgical removal, and histological analysis. Histologically, it was possible to identify a chronic inflammatory, lymphoplasmacytic, and granulomatous reaction, with foreign body giant cells’ reaction, in relation to non-polarizable exogenous material due to the reaction to silicone. The most common complications are granulomas' appearance and material displacement. The case report shows these granulomas are characterized as chronic low-caliber inflammation around the silicone. They have an unknown etiology but are probably multifactorial, from continuous trauma, friction or irritation, iatrogenic factors, infection, immunological mechanisms, and genetic and molecular variations, and can be highly related to the impurity of the injected material.
Medicine and Pharmacology, Dentistry and Oral Surgery
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