Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults' Clinical Characteristics

Renata de Souza Freitas
,
Calliandra Maria De Souza Silva
ORCID logo ,
Caroline Caroline Ferreira Fratelli
ORCID logo ,
Luciano Ramos de Lima
,
Marina Morato Stival
,
Silvana Schwerz Funghetto
ORCID logo ,
Izabel Cristina Rodrigues da Silva
* ORCID logo ,
Rosângela Vieira de Andrade
Version 1 : Received: 5 March 2024 / Approved: 5 March 2024 / Online: 6 March 2024 (11:09:09 CET)

A peer-reviewed article of this Preprint also exists.

Freitas, R.S.; de Souza Silva, C.M.; Ferreira Fratelli, C.; Ramos de Lima, L.; Morato Stival, M.; Schwerz Funghetto, S.; Rodrigues da Silva, I.C.; Vieira de Andrade, R. IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults’ Clinical Characteristics. Nutrients 2024, 16, 1241. Freitas, R.S.; de Souza Silva, C.M.; Ferreira Fratelli, C.; Ramos de Lima, L.; Morato Stival, M.; Schwerz Funghetto, S.; Rodrigues da Silva, I.C.; Vieira de Andrade, R. IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults’ Clinical Characteristics. Nutrients 2024, 16, 1241.

Abstract

Populational aging is marked by chronic non-communicable diseases, such as metabolic syndrome (MetS). IL-10 and IL-1β are pleiotropic cytokines with multiple biological effects linked to metabolic disorders. This cross-sectional study assessed 193 participants' IL-10 and IL-1β serum levels regarding their role in developing MetS, clinical characteristics, and their IL1B rs1143627 and IL10 rs1800890 variants' genotype frequencies in a population over 60. IL-10 levels correlated weakly with HDL levels and fat mass and inversely with triglycerides, glucose, glycated hemoglobin, and estimated average blood glucose levels. IL-10 levels were also indirectly influenced by the patient's T2DM duration, lean mass amount, and bone mineral content. Participants with altered HDL, elevated serum glucose, raised HbA1c levels, or those over 80 had reduced serum IL-10 levels compared to those with normal levels or other age groups, respectively. Women also had higher serum IL-10 levels than men. Dissimilarity, IL-1β levels correlated directly only with the number of total leukocytes and segmented neutrophils, showing only significant variations with self-reported alcohol consumption. Our study also found that those with the IL10 AA genotype (lower IL-10 levels) had a significantly higher risk of developing MetS. These findings may help direct future research and more targeted therapeutic approaches in older adults.

Keywords

Metabolic Syndrome; Interlekine-10; Interlekine-1β; older population; IL10 rs1800890; IL1B rs1143627

Subject

Public Health and Healthcare, Primary Health Care

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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