L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed C. elegans

Liang wen Chen; Gui jie Chen; Ting ting Gai; Xiu hong Zhou; Jin chi Zhu; Rui yi Wang; Xue mei Wang; Yu jie Guo; Yun Wang; Zhong wen Xie

doi:10.20944/preprints202403.0267.v2

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preprints.org > medicine and pharmacology > other > doi: 10.20944/preprints202403.0267.v2

Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed C. elegans

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Version 1 : Received: 5 March 2024 / Approved: 5 March 2024 / Online: 5 March 2024 (12:44:31 CET)
Version 2 : Received: 2 April 2024 / Approved: 2 April 2024 / Online: 3 April 2024 (16:38:00 CEST)

How to cite: Chen, L.W.; Chen, G.J.; Gai, T.T.; Zhou, X.H.; Zhu, J.C.; Wang, R.Y.; Wang, X.M.; Guo, Y.J.; Wang, Y.; Xie, Z.W. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed C. elegans. Preprints 2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v2 Chen, L.W.; Chen, G.J.; Gai, T.T.; Zhou, X.H.; Zhu, J.C.; Wang, R.Y.; Wang, X.M.; Guo, Y.J.; Wang, Y.; Xie, Z.W. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed C. elegans. Preprints 2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v2

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MDPI and ACS Style

Chen, L.W.; Chen, G.J.; Gai, T.T.; Zhou, X.H.; Zhu, J.C.; Wang, R.Y.; Wang, X.M.; Guo, Y.J.; Wang, Y.; Xie, Z.W. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed C. elegans. Preprints 2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v2

APA Style

Chen, L.W., Chen, G.J., Gai, T.T., Zhou, X.H., Zhu, J.C., Wang, R.Y., Wang, X.M., Guo, Y.J., Wang, Y., & Xie, Z.W. (2024). L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed <em>C. elegans</em>. Preprints. https://doi.org/10.20944/preprints202403.0267.v2

Chicago/Turabian Style

Chen, L.W., Yun Wang and Zhong wen Xie. 2024 "L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed <em>C. elegans</em>" Preprints. https://doi.org/10.20944/preprints202403.0267.v2

Abstract

L-Theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effect, regulation of immune response, relaxing neural tension, reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) in UVC-exposed nematodes. In addition, L-theanine treatment also up-regulated the expression of genes related to mitochondrial energy metabolism in UVC-exposed nematodes. Our study provided a theoretical basis for the possibility that tea drinking may prevent mitochondrial related diseases.

Keywords

L-theanine; UVC; mitochondrial DNA damage; C. elegans; lifespan

Subject

Medicine and Pharmacology, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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