L-theanine Prolongs the Lifespan by Activating Multiple Molecular Mechanisms in UVC Exposed C. elegans

Liangwen Chen; Guijie Chen; Tingting Gai; Xiuhong Zhou; Jinchi Zhu; Ruiyi Wang; Xuemei Wang; Yujie Guo; Yun Wang; Zhongwen Xie

doi:10.20944/preprints202403.0267.v1

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preprints.org > medicine and pharmacology > dietetics and nutrition > doi: 10.20944/preprints202403.0267.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

L-theanine Prolongs the Lifespan by Activating Multiple Molecular Mechanisms in UVC Exposed C. elegans

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Version 1 : Received: 5 March 2024 / Approved: 5 March 2024 / Online: 5 March 2024 (12:44:31 CET)
Version 2 : Received: 2 April 2024 / Approved: 2 April 2024 / Online: 3 April 2024 (16:38:00 CEST)

How to cite: Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Mechanisms in UVC Exposed C. elegans. Preprints 2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v1 Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Mechanisms in UVC Exposed C. elegans. Preprints 2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v1

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MDPI and ACS Style

Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Mechanisms in UVC Exposed C. elegans. Preprints 2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v1

APA Style

Chen, L., Chen, G., Gai, T., Zhou, X., Zhu, J., Wang, R., Wang, X., Guo, Y., Wang, Y., & Xie, Z. (2024). L-theanine Prolongs the Lifespan by Activating Multiple Molecular Mechanisms in UVC Exposed C. elegans. Preprints. https://doi.org/10.20944/preprints202403.0267.v1

Chicago/Turabian Style

Chen, L., Yun Wang and Zhongwen Xie. 2024 "L-theanine Prolongs the Lifespan by Activating Multiple Molecular Mechanisms in UVC Exposed C. elegans" Preprints. https://doi.org/10.20944/preprints202403.0267.v1

Abstract

L-theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effect, regulation of immune response, relaxing neural tension, reducing oxidative damage, etc. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) to up-regulate the expression of related genes in UVC-exposed nematodes. In addition, L-theanine treatment also up-regulated the expression of mitochondrial energy metabolism related genes in UVC-exposed nematodes. Our study provided a theoretical basis for the possibility that healthy tea drinking may prevent mitochondrial related diseases.

Keywords

UVC, mitochondrial DNA damage, C. elegans, lifespan, L-theanine

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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