Being Physically Active for a Long-Standing Mitigates Inflammaging Progression in Older Adults during the COVID-19 Pandemic

Carlos André Freitas Dos Santos; Ariane Nardy; Renato Jimenez Gomes; Brenda Rodrigues Silva; Fernanda Rodrigues Monteiro; Marcelo Rossi; Jônatas Bussador do Amaral; Vitória Paixão; Mauro Vaisberg; Gislene Rocha Amirato; Rodolfo de Paula Vieira; Juliana de Melo Batista Dos Santos; Guilherme Eustáquio Furtado; Ana Paula Ribeiro; Patrícia de Souza Colombo; Alessandro Ferrari Jacinto; André Luis Lacerda Bachi

doi:10.20944/preprints202403.0261.v2

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preprints.org > medicine and pharmacology > clinical medicine > doi: 10.20944/preprints202403.0261.v2

Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Being Physically Active for a Long-Standing Mitigates Inflammaging Progression in Older Adults during the COVID-19 Pandemic

Carlos André Freitas Dos Santos

^* ,

Ariane Nardy

Renato Jimenez Gomes

Brenda Rodrigues Silva

Fernanda Rodrigues Monteiro

Marcelo Rossi

Jônatas Bussador do Amaral

Vitória Paixão

Mauro Vaisberg

Gislene Rocha Amirato

Rodolfo de Paula Vieira

Juliana de Melo Batista Dos Santos

Guilherme Eustáquio Furtado

Ana Paula Ribeiro

Patrícia de Souza Colombo

Alessandro Ferrari Jacinto

André Luis Lacerda Bachi

Version 1 : Received: 4 March 2024 / Approved: 5 March 2024 / Online: 5 March 2024 (13:00:16 CET)
Version 2 : Received: 13 March 2024 / Approved: 14 March 2024 / Online: 14 March 2024 (15:05:33 CET)

How to cite: Dos Santos, C.A.F.; Nardy, A.; Gomes, R.J.; Silva, B.R.; Monteiro, F.R.; Rossi, M.; Amaral, J.B.D.; Paixão, V.; Vaisberg, M.; Amirato, G.R.; Vieira, R.D.P.; Dos Santos, J.D.M.B.; Furtado, G.E.; Ribeiro, A.P.; Colombo, P.D.S.; Jacinto, A.F.; Bachi, A.L.L. Being Physically Active for a Long-Standing Mitigates Inflammaging Progression in Older Adults during the COVID-19 Pandemic. Preprints 2024, 2024030261. https://doi.org/10.20944/preprints202403.0261.v2 Dos Santos, C.A.F.; Nardy, A.; Gomes, R.J.; Silva, B.R.; Monteiro, F.R.; Rossi, M.; Amaral, J.B.D.; Paixão, V.; Vaisberg, M.; Amirato, G.R.; Vieira, R.D.P.; Dos Santos, J.D.M.B.; Furtado, G.E.; Ribeiro, A.P.; Colombo, P.D.S.; Jacinto, A.F.; Bachi, A.L.L. Being Physically Active for a Long-Standing Mitigates Inflammaging Progression in Older Adults during the COVID-19 Pandemic. Preprints 2024, 2024030261. https://doi.org/10.20944/preprints202403.0261.v2

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MDPI and ACS Style

Dos Santos, C.A.F.; Nardy, A.; Gomes, R.J.; Silva, B.R.; Monteiro, F.R.; Rossi, M.; Amaral, J.B.D.; Paixão, V.; Vaisberg, M.; Amirato, G.R.; Vieira, R.D.P.; Dos Santos, J.D.M.B.; Furtado, G.E.; Ribeiro, A.P.; Colombo, P.D.S.; Jacinto, A.F.; Bachi, A.L.L. Being Physically Active for a Long-Standing Mitigates Inflammaging Progression in Older Adults during the COVID-19 Pandemic. Preprints 2024, 2024030261. https://doi.org/10.20944/preprints202403.0261.v2

APA Style

Dos Santos, C.A.F., Nardy, A., Gomes, R.J., Silva, B.R., Monteiro, F.R., Rossi, M., Amaral, J.B.D., Paixão, V., Vaisberg, M., Amirato, G.R., Vieira, R.D.P., Dos Santos, J.D.M.B., Furtado, G.E., Ribeiro, A.P., Colombo, P.D.S., Jacinto, A.F., & Bachi, A.L.L. (2024). Being Physically Active for a Long-Standing Mitigates Inflammaging Progression in Older Adults during the COVID-19 Pandemic. Preprints. https://doi.org/10.20944/preprints202403.0261.v2

Chicago/Turabian Style

Dos Santos, C.A.F., Alessandro Ferrari Jacinto and André Luis Lacerda Bachi. 2024 "Being Physically Active for a Long-Standing Mitigates Inflammaging Progression in Older Adults during the COVID-19 Pandemic" Preprints. https://doi.org/10.20944/preprints202403.0261.v2

Abstract

Background: Here, we investigated the inflammaging and physical performance in older adults before and after the COVID-19 pandemic. Methods: Women(n=18) and men(n=7) older were evaluated before the COVID-19 pandemic(PRE), 12 months after the lockdown(POST), and 10 months after resuming exercise training(POS-TR). Physical tests [gait speed(GS) and timed-up-and-go(TUG)]; muscle strength (handgrip-HG), and serum cytokine levels were assessed. Results: The older women showed higher GS and TUG at POST than PRE and POST-TR, besides lower HG at POST-TR than PRE, whereas older men exhibited lower HG at POST and POST-TR than PRE. Both groups presented (1)lower IL-10 and IL-12p70 values in contrast to higher IL-6/IL-10 and IL-8/IL-10 ratios at POST than PRE; (2)higher IL-10 values and lower IL-8/IL-10 ratio at POST-TR than POST; (3)higher IL-12p70/IL-10 ratio at POST-TR than PRE and POST. Particularly older women showed: (4)lower IL-6 values at POST and POST-TR than PRE; (5)lower IL-8 and IL-10 values at POST-TR than POST; (6)and higher TNF-α/IL-10 and IFN-γ/IL-10 ratios at POST than PRE and POST-TR. Significant correlations between the variables were found in both groups. Conclusion: During the COVID-19 pandemic, detraining and resumption of exercise training promoted distinct alterations in physical capacity and inflammaging among older women and older men population.

Keywords

aging; older people; citokines; gait speed; TUGT; handgrip

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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