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Comparison of Intra-operative Analgesia and Peri-Operative Behaviour and Gastrointestinal Motility in Rabbits Receiving a Brachial Plexus Block or Lidocaine Constant Rate Infusion for Orthopaedic Surgery
Version 1
: Received: 4 March 2024 / Approved: 5 March 2024 / Online: 5 March 2024 (05:58:29 CET)
How to cite:
Mead, S.A.; Allen, M.; Elsayad, S.H.; Gittel, C. Comparison of Intra-operative Analgesia and Peri-Operative Behaviour and Gastrointestinal Motility in Rabbits Receiving a Brachial Plexus Block or Lidocaine Constant Rate Infusion for Orthopaedic Surgery. Preprints2024, 2024030234. https://doi.org/10.20944/preprints202403.0234.v1
Mead, S.A.; Allen, M.; Elsayad, S.H.; Gittel, C. Comparison of Intra-operative Analgesia and Peri-Operative Behaviour and Gastrointestinal Motility in Rabbits Receiving a Brachial Plexus Block or Lidocaine Constant Rate Infusion for Orthopaedic Surgery. Preprints 2024, 2024030234. https://doi.org/10.20944/preprints202403.0234.v1
Mead, S.A.; Allen, M.; Elsayad, S.H.; Gittel, C. Comparison of Intra-operative Analgesia and Peri-Operative Behaviour and Gastrointestinal Motility in Rabbits Receiving a Brachial Plexus Block or Lidocaine Constant Rate Infusion for Orthopaedic Surgery. Preprints2024, 2024030234. https://doi.org/10.20944/preprints202403.0234.v1
APA Style
Mead, S.A., Allen, M., Elsayad, S.H., & Gittel, C. (2024). Comparison of Intra-operative Analgesia and Peri-Operative Behaviour and Gastrointestinal Motility in Rabbits Receiving a Brachial Plexus Block or Lidocaine Constant Rate Infusion for Orthopaedic Surgery. Preprints. https://doi.org/10.20944/preprints202403.0234.v1
Chicago/Turabian Style
Mead, S.A., Sara Hassouna Elsayad and Claudia Gittel. 2024 "Comparison of Intra-operative Analgesia and Peri-Operative Behaviour and Gastrointestinal Motility in Rabbits Receiving a Brachial Plexus Block or Lidocaine Constant Rate Infusion for Orthopaedic Surgery" Preprints. https://doi.org/10.20944/preprints202403.0234.v1
Abstract
Locoregional anaesthetic techniques are invaluable for providing multimodal analgesia for painful surgical procedures. This prospective, randomised study describes a nerve stimulator-guided bra-chial plexus blockade (BPB) in rabbits undergoing orthopaedic surgery in comparison to systemic lidocaine.
Premedication was provided with intramuscular (IM) medetomidine, fentanyl and midazolam. Anaesthesia was induced (propofol IV) and maintained with isoflurane. Nine rabbits received a lidocaine BPB (2%; 0.3 ml kg-1), and eight received lidocaine constant rate infusion (CRI) (2 mg kg-1 IV, followed by 100 µg kg-1 minute-1). Rescue analgesia was provided with Fentanyl IV. Carprofen was administered at the end of surgery. Post-operative pain was determined using the Rabbit Grimace Scale (RGS) and a composite pain scale. Buprenorphine was administered accord-ing to pain score for two hours after extubation. Rabbits were filmed during the first two hours to measure distance travelled and behaviours. Food intake and faeces output were compared.
Every rabbit in CRI required intraoperative rescue analgesia compared to no rabbits in BPB. How-ever, rabbits in both groups had similar pain scores and there was no difference in administration of postoperative analgesia. There were no significant differences in food intake or faeces produc-tion over 18 hours, and no significant differences in distance travelled, or behaviours examined during the first two hours.
BPB seems superior for intraoperative analgesia. Postoperatively both groups were comparable.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
