Boudkkazi, S.; Debanne, D. Enhanced Release Probability without Changes in Synaptic Delay during Analogue–Digital Facilitation. Cells2024, 13, 573.
Boudkkazi, S.; Debanne, D. Enhanced Release Probability without Changes in Synaptic Delay during Analogue–Digital Facilitation. Cells 2024, 13, 573.
Boudkkazi, S.; Debanne, D. Enhanced Release Probability without Changes in Synaptic Delay during Analogue–Digital Facilitation. Cells2024, 13, 573.
Boudkkazi, S.; Debanne, D. Enhanced Release Probability without Changes in Synaptic Delay during Analogue–Digital Facilitation. Cells 2024, 13, 573.
Abstract
Neuronal timing is critical for many brain functions such as perception and learning. At the level of the chemical synapse, the synaptic delay is determined by the presynaptic release probability (Pr) and the waveform of the presynaptic action potential (AP). Depolarization-induced analogue-digital facilitation (d-ADF) is a form of context-dependent synaptic facilitation that is induced by constant depolarization of the presynaptic neuron and is mediated by voltage inactivation of presynaptic Kv1 channels. Whether synaptic delay is modulated during d-ADF remains unclear. We show here that despite Pr is elevated during d-ADF at L5-L5 synapses, the synaptic delay is surprisingly unchanged, suggesting that both Pr- and AP-dependent changes in synaptic delay compensate for each other. We conclude that in contrast with other short- or long-term modulation of presynaptic release, timing is not affected during d-ADF because of the opposite interaction of Pr- and AP-dependent modulations of synaptic delay.
Biology and Life Sciences, Neuroscience and Neurology
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