Review
Version 1
Preserved in Portico This version is not peer-reviewed
The current and prospective adjuvant therapies for hepatocel-lular carcinoma
Version 1
: Received: 27 February 2024 / Approved: 4 March 2024 / Online: 4 March 2024 (10:36:35 CET)
A peer-reviewed article of this Preprint also exists.
Du, J.-S.; Hsu, S.-H.; Wang, S.-N. The Current and Prospective Adjuvant Therapies for Hepatocellular Carcinoma. Cancers 2024, 16, 1422. Du, J.-S.; Hsu, S.-H.; Wang, S.-N. The Current and Prospective Adjuvant Therapies for Hepatocellular Carcinoma. Cancers 2024, 16, 1422.
Abstract
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is highly invasive and easily recurs. For HCC, chemotherapy shows a limited effect. The gold standard for HCC treatment includes curative surgical resection or liver transplantation. However, the recur-rence rate at 5 years after liver resection is estimated at approximately 70% and even at 5 years after liver transplantation, it is 20%. Therefore, improving survival outcomes after curative surgi-cal resection of liver cancer is crucial. This review highlights the importance of identifying risk factors for HCC recurrence following radical surgical resection and adjuvant therapy options that may reduce the recurrence risk and improve overall survival, including local adjuvant therapy (e.g., transcatheter arterial chemoembolization and radiotherapy), adjuvant systemic therapy (e.g., small molecule targeted therapy and immunotherapy), and other adjuvant therapies (e.g., chem-otherapy). However, further research is needed to refine the use of these therapies and optimize their effectiveness in preventing HCC recurrence.
Keywords
Hepatocellular carcinoma (HCC); adjuvant therapy; recurrence; improvement
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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