Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Composition and Bioactivity from the Essential Oil of Tetradenia riparia in Pathogenic Bacteria, Aedes aegypti L. (Diptera: Culicidae), and Toxicological Evaluation of Mus musculus (Rodentia: Muridae)

Erica de Menezes Rabelo
,
Rosany Lopes Martins
,
Alex Bruno Lobato Rodrigues
ORCID logo ,
Ridelley de Sousa De Sousa
,
Ana Luzia Ferreira Farias
,
Allan Kardec Ribeiro Galardo
,
Patrick de Castro Cantuária
ORCID logo ,
Rosana Tomazi
,
Sheylla Susan M. da S. de Almeida
* ORCID logo
Version 1 : Received: 29 February 2024 / Approved: 4 March 2024 / Online: 4 March 2024 (10:36:39 CET)

How to cite: Rabelo, E.D.M.; Martins, R.L.; Rodrigues, A.B.L.; De Sousa, R.D.S.; Farias, A.L.F.; Galardo, A.K.R.; Cantuária, P.D.C.; Tomazi, R.; Almeida, S.S.M.D.S.D. Composition and Bioactivity from the Essential Oil of Tetradenia riparia in Pathogenic Bacteria, Aedes aegypti L. (Diptera: Culicidae), and Toxicological Evaluation of Mus musculus (Rodentia: Muridae). Preprints 2024, 2024030105. https://doi.org/10.20944/preprints202403.0105.v1 Rabelo, E.D.M.; Martins, R.L.; Rodrigues, A.B.L.; De Sousa, R.D.S.; Farias, A.L.F.; Galardo, A.K.R.; Cantuária, P.D.C.; Tomazi, R.; Almeida, S.S.M.D.S.D. Composition and Bioactivity from the Essential Oil of Tetradenia riparia in Pathogenic Bacteria, Aedes aegypti L. (Diptera: Culicidae), and Toxicological Evaluation of Mus musculus (Rodentia: Muridae). Preprints 2024, 2024030105. https://doi.org/10.20944/preprints202403.0105.v1

Abstract

Objective: In this work, we evaluated the chemical composition by chromatography coupled to mass spectrometry, antimicrobial and insecticidal activity of essential oils (TrEO) and nanoeffu-sion (NTrEO) of oil from Tetradenia riparia leaves. We also evaluated the acute toxicity in Mus musculus. The results showed that S. aureus showed greater susceptibility to TrEO, with a minimum inhibitory concentration (MIC) of 125 µg.mL-1, when compared to P. aeruginosa, E. coli, which presented a MIC of 250 µg.mL-1. There was a greater toxic effect on TrEO (LC50 = 630.29 µg.mL-1) and NTrEO (LC50 = 713.68 µg.mL-1) larvae, effect on pupae (LC50 = 630.29 µg.mL-1) and NTrEO (LC50 = 713.68 µg.mL-1) and ovicide (LC50 = 631.184 µg.mL-1) and NTrEO (LC50 = 146.701 µg.mL-1) of Ae. aegypti after 24 h of exposure, when compared to other exposure periods. Chemical analysis re-vealed 20 components, aromadendrene oxide (23.47%) being the main component. Female and male mice were used to assess toxicity and oral administration of NTrEO to mice did not result in acute toxicity. Thus, the essential oil of T. riparia and its nanoemulsion have insecticidal and an-timicrobial potential for Ae. aegypti, S. aureus, E. coli, P. aeruginosa, and has a high toxicological safety threshold at the concentrations evaluated in this study.

Keywords

nanoemulsion; oral toxicity; Lamiaceae; phytochemical

Subject

Biology and Life Sciences, Plant Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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