Moiseenko, V.I.; Apryatina, V.A.; Gainetdinov, R.R.; Apryatin, S.A. Trace Amine-Associated Receptors’ Role in Immune System Functions. Biomedicines2024, 12, 893.
Moiseenko, V.I.; Apryatina, V.A.; Gainetdinov, R.R.; Apryatin, S.A. Trace Amine-Associated Receptors’ Role in Immune System Functions. Biomedicines 2024, 12, 893.
Moiseenko, V.I.; Apryatina, V.A.; Gainetdinov, R.R.; Apryatin, S.A. Trace Amine-Associated Receptors’ Role in Immune System Functions. Biomedicines2024, 12, 893.
Moiseenko, V.I.; Apryatina, V.A.; Gainetdinov, R.R.; Apryatin, S.A. Trace Amine-Associated Receptors’ Role in Immune System Functions. Biomedicines 2024, 12, 893.
Abstract
Trace amines are a separate, independent group of biogenic amines, close in structure to classical monoamine neurotransmitters such as dopamine, serotonin and norepinephrine.
G protein-coupled Trace Amine-Associated Receptors (TAAR) are mostly investigated for their involvement in the pathogenesis of neuropsychiatric disorders, but expression of TAAR family receptors is observed also in various populations of cells of the immune system. The review is focused on the basic information on the interaction of trace amines and their receptors with cells of the general immune system of humans and other mammals, as well as on data on TAARs role in the function of individual populations of myeloid and lymphoid cells.
With further research on the regulatory role of the trace amine system in the pathogenesis of the immune response and determination of the biological mechanisms for their action it would be possible to develop new methods for treating diseases related to immune system dysfunctions.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
