Reintroduction of Legacy Antibiotics in Neonatal Sepsis. The Special Role of Fosfomycin and Colistin

Maria Baltogianni; Niki Dermitzaki; Chrysoula Kosmeri; Anastasios Serbis; Foteini Balomenou; Vasileios Giapros

doi:10.20944/preprints202402.1717.v2

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preprints.org > medicine and pharmacology > pediatrics, perinatology and child health > doi: 10.20944/preprints202402.1717.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Reintroduction of Legacy Antibiotics in Neonatal Sepsis. The Special Role of Fosfomycin and Colistin

Version 1 : Received: 28 February 2024 / Approved: 29 February 2024 / Online: 29 February 2024 (12:54:42 CET)
Version 2 : Received: 12 March 2024 / Approved: 14 March 2024 / Online: 14 March 2024 (06:00:58 CET)

A peer-reviewed article of this Preprint also exists.

Baltogianni, M.; Dermitzaki, N.; Kosmeri, C.; Serbis, A.; Balomenou, F.; Giapros, V. Reintroduction of Legacy Antibiotics in Neonatal Sepsis: The Special Role of Fosfomycin and Colistin. Antibiotics 2024, 13, 333. Baltogianni, M.; Dermitzaki, N.; Kosmeri, C.; Serbis, A.; Balomenou, F.; Giapros, V. Reintroduction of Legacy Antibiotics in Neonatal Sepsis: The Special Role of Fosfomycin and Colistin. Antibiotics 2024, 13, 333.

Abstract

Neonatal sepsis is a leading cause of morbidity and mortality in neonates, particularly in low and middle-income countries. The emergence of antimicrobial resistance is a rapidly growing global problem. A significant proportion of the pathogens that commonly cause neonatal sepsis are resistant to multiple antibiotics. Therefore, for the empirical treatment of neonatal sepsis, the repurposing of older antibiotics that are effective against multidrug-resistant pathogens is being investigated. This review aims to provide an overview of current research and experience using the repurposed antibiotics, Colistin and Fosfomycin, for the empirical treatment of neonatal sepsis. Based on current knowledge, Colistin and Fosfomycin may be potentially helpful for the empirical treatment of sepsis in neonates due to their efficacy against a wide range of pathogens and acceptable safety profile.

Keywords

neonatal sepsis; antimicrobial resistance; repurposed antibiotics; Colistin; Fosfomycin

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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