Carter, C.; Laviolette, L.; Bietar, B.; Zhou, J.; Lehmann, C. Cannabis, Cannabinoids, and Stroke: Increased Risk or Potential for Protection—A Narrative Review. Curr. Issues Mol. Biol.2024, 46, 3122-3133.
Carter, C.; Laviolette, L.; Bietar, B.; Zhou, J.; Lehmann, C. Cannabis, Cannabinoids, and Stroke: Increased Risk or Potential for Protection—A Narrative Review. Curr. Issues Mol. Biol. 2024, 46, 3122-3133.
Carter, C.; Laviolette, L.; Bietar, B.; Zhou, J.; Lehmann, C. Cannabis, Cannabinoids, and Stroke: Increased Risk or Potential for Protection—A Narrative Review. Curr. Issues Mol. Biol.2024, 46, 3122-3133.
Carter, C.; Laviolette, L.; Bietar, B.; Zhou, J.; Lehmann, C. Cannabis, Cannabinoids, and Stroke: Increased Risk or Potential for Protection—A Narrative Review. Curr. Issues Mol. Biol. 2024, 46, 3122-3133.
Abstract
Worldwide, approximately 15 million people per year suffer from stroke. With about 5 million deaths, stroke is the second most common cause of death and a major cause of long-term disability. It is estimated that about 25% of people older than 85 years will develop stroke. Cannabis sativa and derived cannabinoids are used for recreational and medical purposes for many centuries. However, due to past legal status, research faced restrictions and cannabis use was stigmatized for potential negative impacts on health. With the legalization of cannabis in many countries of the world, cannabis and cannabis-derived substances such as cannabinoids and terpenes have gained more interest in medical research. Several medical effects of cannabis have been scientifically proven and potential risks were identified. In the context of stroke, the role of cannabis is controversial. Negative impact of cannabis use on stroke has been reported through anecdotal case reports and some population-based studies. However, potential beneficial effects of specific cannabinoids are described in animal studies under certain conditions. In this review, the existing body of evidence regarding the negative and positive impacts of cannabis use prior to stroke will be critically appraised.
Keywords
Cannabis; cannabinoid; stroke; neuroprotection
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
