Article
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What do Stimulated Beta Cells have in Common with Cancer Cells?
Version 1
: Received: 22 February 2024 / Approved: 23 February 2024 / Online: 23 February 2024 (09:16:13 CET)
How to cite: Marhl, M. What do Stimulated Beta Cells have in Common with Cancer Cells?. Preprints 2024, 2024021341. https://doi.org/10.20944/preprints202402.1341.v1 Marhl, M. What do Stimulated Beta Cells have in Common with Cancer Cells?. Preprints 2024, 2024021341. https://doi.org/10.20944/preprints202402.1341.v1
Abstract
This study investigates the metabolic parallels between stimulated pancreatic beta cells and cancer cells, emphasizing glucose and glutamine metabolism. Addressing the significant public health challenges of Type 2 Diabetes Mellitus (T2DM) and cancer, we aim to deepen understanding of the mechanisms driving insulin secretion and cellular proliferation. Our analysis of anaplerotic cycles and NADPH's role in biosynthesis elucidates their vital functions in both processes. Additionally, we find that both cell types share an antioxidative response mediated by the Nrf2 signaling pathway, glutathione synthesis, and UCP2 upregulation. Notably, UCP2 facilitates the transfer of C4 metabolites, enhancing reductive TCA cycle metabolism. We also uncover that hypoxic responses are transient in beta cells post-stimulation but persistent in cancer cells. By synthesizing these insights, our research suggests novel therapeutic targets for T2DM, highlighting the shared metabolic strategies of stimulated beta cells and cancer cells. This comparative analysis not only illuminates the metabolic complexity of these conditions but also emphasizes the crucial role of metabolic pathways in cell function and survival, offering fresh perspectives for tackling T2DM and cancer challenges.
Keywords
Diabetes; Cancer; Reductive metabolism; NADPH; GSH; Nrf2 pathway; UCP2; Succinate; HIF
Subject
Biology and Life Sciences, Biophysics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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