Version 1
: Received: 19 February 2024 / Approved: 20 February 2024 / Online: 20 February 2024 (06:32:48 CET)
How to cite:
Walsh, D.; Bevan, J.; Harrison, F. How Does Airway Surface Liquid Composition Vary in Different Pulmonary Diseases, and How Can We Use This Knowledge to Model Microbial Infections?. Preprints2024, 2024021101. https://doi.org/10.20944/preprints202402.1101.v1
Walsh, D.; Bevan, J.; Harrison, F. How Does Airway Surface Liquid Composition Vary in Different Pulmonary Diseases, and How Can We Use This Knowledge to Model Microbial Infections?. Preprints 2024, 2024021101. https://doi.org/10.20944/preprints202402.1101.v1
Walsh, D.; Bevan, J.; Harrison, F. How Does Airway Surface Liquid Composition Vary in Different Pulmonary Diseases, and How Can We Use This Knowledge to Model Microbial Infections?. Preprints2024, 2024021101. https://doi.org/10.20944/preprints202402.1101.v1
APA Style
Walsh, D., Bevan, J., & Harrison, F. (2024). How Does Airway Surface Liquid Composition Vary in Different Pulmonary Diseases, and How Can We Use This Knowledge to Model Microbial Infections?. Preprints. https://doi.org/10.20944/preprints202402.1101.v1
Chicago/Turabian Style
Walsh, D., Jennifer Bevan and Freya Harrison. 2024 "How Does Airway Surface Liquid Composition Vary in Different Pulmonary Diseases, and How Can We Use This Knowledge to Model Microbial Infections?" Preprints. https://doi.org/10.20944/preprints202402.1101.v1
Abstract
Growth environment greatly alters many facets of pathogen physiology, including pathogenesis and antimicrobial tolerance. The importance of host-mimicking environments for attaining an accurate picture of pathogen behaviour is widely recognised. Whilst this recognition has translated into the extensive development of artificial cystic fibrosis (CF) sputum medium, attempts to mimic the growth environment in other respiratory disease states have been completely neglected. The composition of the airway surface liquid (ASL) in different pulmonary diseases is far less well characterised than CF sputum, making it very difficult for researchers to model these infection environments. In this review we discuss the components of human ASL, how different lung pathologies affect ASL composition, and how different pathogens interact with these components. This will provide researchers interested in mimicking different respiratory environments with the information necessary to design a host-mimicking medium, allowing for better understanding of how to treat pathogens causing infection in these environments.
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
