Version 1
: Received: 16 February 2024 / Approved: 19 February 2024 / Online: 19 February 2024 (10:25:40 CET)
Version 2
: Received: 19 February 2024 / Approved: 20 February 2024 / Online: 20 February 2024 (07:07:17 CET)
Version 3
: Received: 20 February 2024 / Approved: 21 February 2024 / Online: 21 February 2024 (04:14:22 CET)
Version 4
: Received: 15 March 2024 / Approved: 15 March 2024 / Online: 18 March 2024 (08:36:12 CET)
How to cite:
Aftab, A.; Basu, A.; Nath, S.; Basu, S. Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multi-functionality. Preprints2024, 2024021029. https://doi.org/10.20944/preprints202402.1029.v4
Aftab, A.; Basu, A.; Nath, S.; Basu, S. Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multi-functionality. Preprints 2024, 2024021029. https://doi.org/10.20944/preprints202402.1029.v4
Aftab, A.; Basu, A.; Nath, S.; Basu, S. Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multi-functionality. Preprints2024, 2024021029. https://doi.org/10.20944/preprints202402.1029.v4
APA Style
Aftab, A., Basu, A., Nath, S., & Basu, S. (2024). Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multi-functionality. Preprints. https://doi.org/10.20944/preprints202402.1029.v4
Chicago/Turabian Style
Aftab, A., Seema Nath and Sankar Basu. 2024 "Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multi-functionality" Preprints. https://doi.org/10.20944/preprints202402.1029.v4
Abstract
The evolution of human societal dynamics over the course of decades and centuries has led toan ever-increasingly complex digital modern life, one of the hallmark of which is the need for multi-tasking, inclusive of that with media. Is there an empirical mapping between this macroscopic(digital)evolution of the human societal dynamics (in terms of multi-tasking)and the microscopic evolution of the functionalmolecular units within cells (i.e., proteins) and their manifold cross-talks? Multi-tasking requires a certain degree of intrinsic or adapted flexibility which is as true at the bio-molecular level. Evolutionary diversification of structure-function relationship in proteins emphasizes the functional importance of intrinsically disordered entities (IDPs/IDRs) which are highly dynamic biological soft matters. Multi-functionality is favorably supported by theirfluid-like shapes and other new malleable members of the protein family. The new wealth of knowledge coming from recent research on protein intrinsic disorder, fold-switching, moonlighting, hub proteins etc. has given us new insights into protein structure – functional relationship. This has led to a paradigm shift in protein science, clearly diverging from the traditional 'one structure – one function' model applicable to enzyme classes to a more complex understanding of protein functionality. This paradigm shift has caused scientists to delve deeper into the subject, exploring various evolutionary toys and tools to fit the cumulative multi-functionaldemands in higher organisms. This commentary covers thedifferent evolutionary arsenals to achieve the growing multi-functionalityand argues in favor of protein intrinsic disorder as probably the sharpest weapon of all.
Keywords
Protein multi-functionality; Intrinsically Disordered Proteins; Gene duplication; Domain Shuffling; Protein moonlighting
Subject
Biology and Life Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
