Version 1
: Received: 16 February 2024 / Approved: 19 February 2024 / Online: 19 February 2024 (10:25:40 CET)
Version 2
: Received: 19 February 2024 / Approved: 20 February 2024 / Online: 20 February 2024 (07:07:17 CET)
Version 3
: Received: 20 February 2024 / Approved: 21 February 2024 / Online: 21 February 2024 (04:14:22 CET)
Version 4
: Received: 15 March 2024 / Approved: 15 March 2024 / Online: 18 March 2024 (08:36:12 CET)
How to cite:
Aftab, A.; Basu, A.; Nath, S.; Basu, S. The Evolutionary Mapping of Intrinsic Disorder and Evolved Protein Multi-functionality (Commentary). Preprints2024, 2024021029. https://doi.org/10.20944/preprints202402.1029.v3
Aftab, A.; Basu, A.; Nath, S.; Basu, S. The Evolutionary Mapping of Intrinsic Disorder and Evolved Protein Multi-functionality (Commentary). Preprints 2024, 2024021029. https://doi.org/10.20944/preprints202402.1029.v3
Aftab, A.; Basu, A.; Nath, S.; Basu, S. The Evolutionary Mapping of Intrinsic Disorder and Evolved Protein Multi-functionality (Commentary). Preprints2024, 2024021029. https://doi.org/10.20944/preprints202402.1029.v3
APA Style
Aftab, A., Basu, A., Nath, S., & Basu, S. (2024). The Evolutionary Mapping of Intrinsic Disorder and Evolved Protein Multi-functionality (Commentary). Preprints. https://doi.org/10.20944/preprints202402.1029.v3
Chicago/Turabian Style
Aftab, A., Seema Nath and Sankar Basu. 2024 "The Evolutionary Mapping of Intrinsic Disorder and Evolved Protein Multi-functionality (Commentary)" Preprints. https://doi.org/10.20944/preprints202402.1029.v3
Abstract
The evolution of human societal dynamics over the course of decades and centuries has led toan ever-increasingly complex digital modern life, one of the hallmark of which is the need for multi-tasking, inclusive of that with media. Is there an empirical mapping between this macroscopic(digital)evolution of the human societal dynamicsand the microscopic evolution of the functionalmolecular units within cells and their manifold cross-talks? The relatively new wealth of knowledge coming from recent research on protein intrinsic disorder, fold-switching, domain shuffling, moonlighting, hub proteins etc. has given us new insights into protein structure – functional relationship. This has led to a paradigm shift in protein science, clearly diverging from the traditional 'one structure – one function' model applicable to enzyme classes to a more complex understanding of protein functionality. This paradigm shift has caused scientists to delve deeper into the subject, exploring the philosophical as well as the scientific basis of evolved protein multi-functionality, expressed by various evolutionary toys and tools to fit the cumulative multi-functionaldemands in higher organisms. This commentary covers thedifferent evolutionary arsenals to achieve the growing multi-functionalityand argues in favor of protein intrinsic disorder as probably the sharpest weapon of all.
Keywords
Protein multi-functionality; Intrinsically Disordered Proteins; Gene duplication; Domain Shuffling; Protein moonlighting
Subject
Biology and Life Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
