Xu, S.; Larsson, A.; Lind, L.; Lindskog, C.; Ärnlöv, J.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus? J. Clin. Med.2024, 13, 2629.
Xu, S.; Larsson, A.; Lind, L.; Lindskog, C.; Ärnlöv, J.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus? J. Clin. Med. 2024, 13, 2629.
Xu, S.; Larsson, A.; Lind, L.; Lindskog, C.; Ärnlöv, J.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus? J. Clin. Med.2024, 13, 2629.
Xu, S.; Larsson, A.; Lind, L.; Lindskog, C.; Ärnlöv, J.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus? J. Clin. Med. 2024, 13, 2629.
Abstract
A previous report showed that the urine output of HPLBII-P in patients with diabetes mellitus and SARS-Cov-2 infection was increased as a sign of glomerular dysfunction. . The aim of this report was to investigate the relation of urine output of HPLBII-P to diabetes mellitus in two large community-based elderly populations i.e. the ULSAM and PIVUS cohorts.
Methods
HPLBII-P was measured by ELISA in the urine of a community-based cohort of 839 men (ULSAM) collected at 77 years of age and in urine of a community-based cohort of 75-year-old men, n=387, and women, n=401 (PIVUS). KIM-1, NGAL and Albumin were measured in urine and Cathepsin S and Cystatin C in serum.
Results
HPLBII-P was significantly raised among males with diabetes in the ULSAM (p
Keywords
nephropathy; biomarker; podocyte
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
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