Version 1
: Received: 15 February 2024 / Approved: 15 February 2024 / Online: 16 February 2024 (11:34:01 CET)
How to cite:
Xu, S.; Larsson, A.; Lind, L.; Lindskog, C.; Ärnlöv, J.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Function and Activity in Diabetes Mellitus. Preprints2024, 2024020905. https://doi.org/10.20944/preprints202402.0905.v1
Xu, S.; Larsson, A.; Lind, L.; Lindskog, C.; Ärnlöv, J.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Function and Activity in Diabetes Mellitus. Preprints 2024, 2024020905. https://doi.org/10.20944/preprints202402.0905.v1
Xu, S.; Larsson, A.; Lind, L.; Lindskog, C.; Ärnlöv, J.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Function and Activity in Diabetes Mellitus. Preprints2024, 2024020905. https://doi.org/10.20944/preprints202402.0905.v1
APA Style
Xu, S., Larsson, A., Lind, L., Lindskog, C., Ärnlöv, J., & Venge, P. (2024). The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Function and Activity in Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202402.0905.v1
Chicago/Turabian Style
Xu, S., Johan Ärnlöv and Per Venge. 2024 "The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Function and Activity in Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202402.0905.v1
Abstract
A previous report showed that the urine output of HPLBII-P in patients with diabetes mellitus and SARS-Cov-2 infection was increased as a sign of glomerular dysfunction. . The aim of this report was to investigate the relation of urine output of HPLBII-P to diabetes mellitus in two large community-based elderly populations i.e. the ULSAM and PIVUS cohorts.
Methods
HPLBII-P was measured by ELISA in the urine of a community-based cohort of 839 men (ULSAM) collected at 77 years of age and in urine of a community-based cohort of 75-year-old men, n=387, and women, n=401 (PIVUS). KIM-1, NGAL and Albumin were measured in urine and Cathepsin S and Cystatin C in serum.
Results
HPLBII-P was significantly raised among males with diabetes in the ULSAM (p
Keywords
nephropathy; biomarker; podocyte
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
