Clinical Significance and Remaining Issues of Anti‐ HBc Antibody and HBV Core‐Related Antigen

Yoshihiko Yano; Itsuko Sato; Takamitsu Imanishi; Ryutaro Yoshida; Takanori Matsuura; Yoshihide Ueda; Yuzo Kodama

doi:10.20944/preprints202402.0759.v1

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preprints.org > medicine and pharmacology > gastroenterology and hepatology > doi: 10.20944/preprints202402.0759.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Significance and Remaining Issues of Anti‐ HBc Antibody and HBV Core‐Related Antigen

^* ,

Version 1 : Received: 13 February 2024 / Approved: 13 February 2024 / Online: 14 February 2024 (09:11:13 CET)

A peer-reviewed article of this Preprint also exists.

Yano, Y.; Sato, I.; Imanishi, T.; Yoshida, R.; Matsuura, T.; Ueda, Y.; Kodama, Y. Clinical Significance and Remaining Issues of Anti-HBc Antibody and HBV Core-Related Antigen. Diagnostics 2024, 14, 728. Yano, Y.; Sato, I.; Imanishi, T.; Yoshida, R.; Matsuura, T.; Ueda, Y.; Kodama, Y. Clinical Significance and Remaining Issues of Anti-HBc Antibody and HBV Core-Related Antigen. Diagnostics 2024, 14, 728.

Abstract

Currently, hepatitis B virus (HBV) core antibody (anti-HBc antibody) and HBV core-related antigen (HBcrAg) are widely used as serum markers for diagnosis based on the HBV core region. While anti-HBc is very significant for clinical diagnosis, the clinical significance of quantitative assay of anti-HBc antibody has been reevaluated with improvements in diagnostic performance, including its association with clinical stage and prediction of carcinogenesis and reactivation. In addition, concerning the new HBcrAg, a high-sensitivity assay method has recently been established, and its diagnostic significance, including the prediction of reactivation, is being reevaluated. On the other hand, the quantitative level of anti-HBc antibody expressed in different units among assay systems, complicating the interpretation of the results. However, it is difficult to standardize assay systems as they vary in advantages, and caution is needed in interpreting the assay results. In this review, the clinical usefulness and remaining problems of anti-HBc antibody and HBcrAg were summarized.

Keywords

anti-HBc antibody; HBV core-related antigen; HBV

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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