Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review

Version 1 : Received: 12 February 2024 / Approved: 13 February 2024 / Online: 13 February 2024 (08:25:27 CET)

A peer-reviewed article of this Preprint also exists.

Kulesa-Mrowiecka, M.; Lipowicz, A.; Marszałek-Kruk, B.A.; Kania, D.; Wolański, W.; Myśliwiec, A.; Dowgierd, K. Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review. Children 2024, 11, 399. Kulesa-Mrowiecka, M.; Lipowicz, A.; Marszałek-Kruk, B.A.; Kania, D.; Wolański, W.; Myśliwiec, A.; Dowgierd, K. Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review. Children 2024, 11, 399.

Abstract

Introduction: Cleft lip with or without cleft palate (CL/P) is the most common congenital face anomaly in the world of multifactorial etiology. Objective: To determine the prevalence and characteristics of cleft palate. To identify associated risk factors to guide prevention and/or prenatal detection for early intervention and better health outcomes. To assess the rehabilitation protocols after operations in cleft palate. Design: Retrospective descriptive and clinical study. Patients: One hundred and three children with cleft palate treated in the Department of Head and Neck Surgery Clinic for Children and Young Adults, Department of Clinical Pediatrics, University of Warmia and Mazury, were included in the study. Methods: Records evaluation was conducted regarding sex, cleft type, mother occupation, parents education, histories of cleft in any of parents. The data were analyzed using R (R core team 2021) and the ordinal logistic regression analyses. Results: Children of stressed mothers during pregnancy had 9.4 times higher odds of having bilateral cleft. While there was no evidence that children sex, order of birth, and body mass as well as risk of maternal toxicity at work or reporting infections or drugs toxicity had a significant effect on the dependent variable. Conclusions: Children of parents with cleft history and having low educated mothers had higher probability of bilateral cleft palate. Children of stressed mothers during pregnancy had higher odds of having bilateral cleft. In literature, there is a lack of reports about rehabilitation in different operations methods in children with cleft palates.

Keywords

cleft lip and palate; aethiology; rehabilitation; risk factors

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

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