Version 1
: Received: 9 February 2024 / Approved: 12 February 2024 / Online: 12 February 2024 (10:27:22 CET)
How to cite:
Tesfay, T.; Mulaw, G.; Tadege, T.; Aregawi, G. Antibacterial Activity of Cyphostemma junceum and Senna singueana Extracts against Staphylococcus aureus and Pseudomonas aeruginosa. Preprints2024, 2024020664. https://doi.org/10.20944/preprints202402.0664.v1
Tesfay, T.; Mulaw, G.; Tadege, T.; Aregawi, G. Antibacterial Activity of Cyphostemma junceum and Senna singueana Extracts against Staphylococcus aureus and Pseudomonas aeruginosa. Preprints 2024, 2024020664. https://doi.org/10.20944/preprints202402.0664.v1
Tesfay, T.; Mulaw, G.; Tadege, T.; Aregawi, G. Antibacterial Activity of Cyphostemma junceum and Senna singueana Extracts against Staphylococcus aureus and Pseudomonas aeruginosa. Preprints2024, 2024020664. https://doi.org/10.20944/preprints202402.0664.v1
APA Style
Tesfay, T., Mulaw, G., Tadege, T., & Aregawi, G. (2024). Antibacterial <span aria-describedby="tippy-18">Activity of Cyphostemma junceum and Senna singueana Extracts against Staphylococcus aureus and Pseudomonas aeruginosa. Preprints. https://doi.org/10.20944/preprints202402.0664.v1
Chicago/Turabian Style
Tesfay, T., Tekleweyni Tadege and Gebremichael Aregawi. 2024 "Antibacterial <span aria-describedby="tippy-18">Activity of Cyphostemma junceum and Senna singueana Extracts against Staphylococcus aureus and Pseudomonas aeruginosa" Preprints. https://doi.org/10.20944/preprints202402.0664.v1
Abstract
The emergence of multidrug-resistant strains of many pathogens is a serious threat and makes chemotherapy more difficult. The main objective of this study was to evaluate the antibacterial activity of Senna singueana and Cyphostemma junceum plant extracts against Staphylococcus aureus and Pseudomonas aeruginosa. The crude extracts of the selected medicinal plants were prepared and subjected to phytochemical screening using standard methods. Antibacterial activity was determined using the disc diffusion method. Therefore, the highest (15.41%) and lowest (0.91%) percentage yields were obtained from ethanol stem bark extracts and chloroform root extracts of Senna singueana, respectively. The maximum (14±1.0 mm) and minimum (7.5±0.5 mm) zones of inhibition were obtained from chloroform and distilled water leaf extracts of Senna singueana against Pseudomonas aeruginosa, respectively. In addition, the highest (13.5±1.0) zone of inhibition was obtained from Cyphostemma junceun root extract at 125 µg/ml. No inhibition zones were recorded in the root extract of Cyphostemma junceun at 500 µg/ml. More rich secondary metabolites, such as flavonoids, tennins, phenols, glycosides, terpenoids and sapnoids, were screened from distilled water leaf extracts, while flavonoids, tennis, phenols, glycosides, terpenoids, sapnoids and coumarins were screened in ethanol root extracts of Cyphostemma junceum. The leaves, stem bark and root of Senna singueana as well as the root of Cyphostemma junceun have strong antibacterial activity against both bacterial species. Thus, the two plant extracts could be used for healing and killing bacterial agents that can be potential sources for drug development.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
