Version 1
: Received: 10 February 2024 / Approved: 12 February 2024 / Online: 12 February 2024 (08:53:17 CET)
How to cite:
Al Shuaili, H.H.; Al Mashikhi, B.A.; Sinani, A.A.; Al-Busafi, S.A. High Prevalence and Risk Factors of Significant Hepatic Fibrosis in Omani Hepatitis B Inactive Carriers: A Retrospective Study. Preprints2024, 2024020622. https://doi.org/10.20944/preprints202402.0622.v1
Al Shuaili, H.H.; Al Mashikhi, B.A.; Sinani, A.A.; Al-Busafi, S.A. High Prevalence and Risk Factors of Significant Hepatic Fibrosis in Omani Hepatitis B Inactive Carriers: A Retrospective Study. Preprints 2024, 2024020622. https://doi.org/10.20944/preprints202402.0622.v1
Al Shuaili, H.H.; Al Mashikhi, B.A.; Sinani, A.A.; Al-Busafi, S.A. High Prevalence and Risk Factors of Significant Hepatic Fibrosis in Omani Hepatitis B Inactive Carriers: A Retrospective Study. Preprints2024, 2024020622. https://doi.org/10.20944/preprints202402.0622.v1
APA Style
Al Shuaili, H.H., Al Mashikhi, B.A., Sinani, A.A., & Al-Busafi, S.A. (2024). High Prevalence and Risk Factors of Significant Hepatic Fibrosis in Omani Hepatitis B Inactive Carriers: A Retrospective Study. Preprints. https://doi.org/10.20944/preprints202402.0622.v1
Chicago/Turabian Style
Al Shuaili, H.H., Ahmed Al Sinani and Said A. Al-Busafi. 2024 "High Prevalence and Risk Factors of Significant Hepatic Fibrosis in Omani Hepatitis B Inactive Carriers: A Retrospective Study" Preprints. https://doi.org/10.20944/preprints202402.0622.v1
Abstract
Background: Despite their generally favorable prognosis, hepatic fibrosis remains a possible complication for hepatitis B virus (HBV) inactive carriers. This study aimed to estimate the prevalence of significant fibrosis and associated risk factors among Omani HBV inactive carriers. Methods: A retrospective study was conducted of 200 Omani HBV inactive carriers visiting a tertiary hospital in Muscat, Oman, between January 2017 and December 2018. Significant fibrosis (stage F2 or higher) was identified using two-dimensional shear-wave elastography. Baseline clinical, laboratory, and radiological data were analyzed to determine associations. Results: Of the total sample, 106 patients (53%) were male, and the mean age was 44.6 ± 9.3 years. The prevalence of significant fibrosis was 20% (n = 40). Male gender (p = 0.007), age ≥60 years (p = 0.024), and fatty changes in liver ultrasound (p = 0.044) were found to be independent factors for significant fibrosis. Conclusion: the prevalence of significant fibrosis was relatively high among a sample of Omani HBV inactive carriers, with several sociodemographic and clinical risk factors identified. Periodic assessment of liver function is needed for patients with these risk factors; moreover, routine biochemical parameters could be useful predictors of disease prognosis. Further research is recommended to substantiate these findings.
Keywords
Hepatitis B Inactive Carriers; Hepatic Fibrosis; Prevalence; Risk Factors; Oman
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
