Version 1
: Received: 9 February 2024 / Approved: 10 February 2024 / Online: 12 February 2024 (09:47:57 CET)
How to cite:
Maldonado, M.; Sanabria, E.; Romero, C.M.; Esteso, M.A. New Contributions to the Study of the Interaction between Hydrocortisone and Hydroxypropyl-Cyclodextrins in Aqueous Solution. Preprints2024, 2024020612. https://doi.org/10.20944/preprints202402.0612.v1
Maldonado, M.; Sanabria, E.; Romero, C.M.; Esteso, M.A. New Contributions to the Study of the Interaction between Hydrocortisone and Hydroxypropyl-Cyclodextrins in Aqueous Solution. Preprints 2024, 2024020612. https://doi.org/10.20944/preprints202402.0612.v1
Maldonado, M.; Sanabria, E.; Romero, C.M.; Esteso, M.A. New Contributions to the Study of the Interaction between Hydrocortisone and Hydroxypropyl-Cyclodextrins in Aqueous Solution. Preprints2024, 2024020612. https://doi.org/10.20944/preprints202402.0612.v1
APA Style
Maldonado, M., Sanabria, E., Romero, C.M., & Esteso, M.A. (2024). New Contributions to the Study of the Interaction between Hydrocortisone and Hydroxypropyl-Cyclodextrins in Aqueous Solution. Preprints. https://doi.org/10.20944/preprints202402.0612.v1
Chicago/Turabian Style
Maldonado, M., Carmen Maria Romero and Miguel A. Esteso. 2024 "New Contributions to the Study of the Interaction between Hydrocortisone and Hydroxypropyl-Cyclodextrins in Aqueous Solution" Preprints. https://doi.org/10.20944/preprints202402.0612.v1
Abstract
In the present work, the interactions between hydrocortisone and cyclodextrins were investigated. The cyclodextrins selected for this study were hydroxypropyl-α-cyclodextrin, hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin. The study was carried out using density measurements, 1H-NMR and FT-IR spectroscopy. Preliminary studies show that hydroxypropyl-α-cyclodextrin has a low affinity for hydrocortisone, while hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin have a good affinity for hydrocortisone in both solid state and solution. The study was carried out at two temperatures: 298.15 K and 310.15 K. The results suggest that at both temperatures, the system 2-HP-β-CD + HC induces an increase in the solvent structure, with increasing the solute concentration in the solution, while on the contrary the system 2-HP-γ-CD + HC induces a decrease in the solvent structure when the concentration of the solute in the system increases.
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
