Therapeutic Potential of Clusterin Inhibition in Human Cancer

Martín-García, D.; García-Aranda, M.; Redondo, M. Therapeutic Potential of Clusterin Inhibition in Human Cancer. Cells 2024, 13, 665. Martín-García, D.; García-Aranda, M.; Redondo, M. Therapeutic Potential of Clusterin Inhibition in Human Cancer. Cells 2024, 13, 665.

Abstract

Clusterin (CLU) protein is involved in various pathophysiological processes including carcinogenesis and tumor progression. In recent years, the role of the secretory isoform has been demonstrated in tumor cells, where it inhibits apoptosis and favors the acquisition of resistance to conventional treatments used to treat cancer. To determine the possible therapeutic potential of inhibiting this protein, numerous studies have been carried out in this field. In this paper, we show the existing knowledge on the inhibition of this protein in different types of cancer and discuss the importance it could have in the development of new therapies directed against this pathology.

Keywords

clusterin; human cancer; targeted treatment; resistance; therapeutic potential.

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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