Diversity of the Japanese Gut Microbiome

Tatsuki Itagaki; Ken-ichiro Sakata; Akira Hasebe; Yoshimasa Kitagawa

doi:10.20944/preprints202402.0275.v1

Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 2 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (13:17:52 CET)
Version 2 : Received: 19 February 2024 / Approved: 19 February 2024 / Online: 19 February 2024 (15:27:25 CET)
Version 3 : Received: 11 March 2024 / Approved: 11 March 2024 / Online: 11 March 2024 (16:59:03 CET)

Firmicutes and Bacteroidetes, the major phyla in the colon, have been observed in humans worldwide. Gut microbiome analyses often use the Firmicutes/Bacteroidetes ratio and principal coordinates analysis (PCoA). However, misinformation is pervasive in the human microbiome literature and analysis. An attempt was made to demonstrate how to analyze using the “National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN JMD) (Public Data).” The results showed that PCoA did not work, and principal component analysis (PCA) was useful for analyzing the gut microbiome alpha diversity.

gut microbiome; compositional data; principal component analysis; machine learning; diversity

Biology and Life Sciences, Biology and Biotechnology

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Diversity of the Japanese Gut Microbiome

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