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Frankincense (Boswellia serrata) Extract Effects on the Growth, Biofilm Formation, and Intracellular Infection of Porphyromonas gingivalis and Fusobacterium nucleatum in Human Gingival Epithelial Cells
Vang, D.; Moreira-Souza, A.C.A.; Zusman, N.; Moncada, G.; Dakafay, H.M.; Asadi, H.; Ojcius, D.M.; Almeida-da-Silva, C.L.C. Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells. Curr. Issues Mol. Biol.2024, 46, 2991-3004.
Vang, D.; Moreira-Souza, A.C.A.; Zusman, N.; Moncada, G.; Dakafay, H.M.; Asadi, H.; Ojcius, D.M.; Almeida-da-Silva, C.L.C. Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells. Curr. Issues Mol. Biol. 2024, 46, 2991-3004.
Vang, D.; Moreira-Souza, A.C.A.; Zusman, N.; Moncada, G.; Dakafay, H.M.; Asadi, H.; Ojcius, D.M.; Almeida-da-Silva, C.L.C. Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells. Curr. Issues Mol. Biol.2024, 46, 2991-3004.
Vang, D.; Moreira-Souza, A.C.A.; Zusman, N.; Moncada, G.; Dakafay, H.M.; Asadi, H.; Ojcius, D.M.; Almeida-da-Silva, C.L.C. Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells. Curr. Issues Mol. Biol. 2024, 46, 2991-3004.
Abstract
Boswellia trees are the source of frankincense, which can be found throughout the Middle East and parts of Africa and Asia. Boswellia serrata extract has been shown to have anti-cancer, anti-inflammatory, and anti-microbial effects. Periodontitis is an oral chronic inflammatory disease that affects nearly half of the US population. We investigated the antimicrobial effects of B. serrata extract on two oral pathogens associated with periodontitis. Using the minimum inhibitory concentration and crystal violet staining methods, we demonstrated that Porphyromonas gingivalis growth and biofilm formation were impaired by treatment with B. serrata extracts. However, there were no significant effects on Fusobacterium nucleatum growth and biofilm formation. Using colony-forming units quantification and microscopy techniques, we also showed that concentrations of B. serrata that were not toxic for host cells decreased intracellular P. gingivalis infection in human gingival epithelial cells. Our results show antimicrobial activity of a natural product extracted from Boswellia trees (B. serrata) against periodontopathogens. Thus, B. serrata has the therapeutic potential for preventing and/or treating periodontal diseases. Future studies will identify molecular components of B. serrata extracts responsible for the beneficial effects.
Biology and Life Sciences, Immunology and Microbiology
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