Version 1
: Received: 31 January 2024 / Approved: 1 February 2024 / Online: 1 February 2024 (12:58:00 CET)
How to cite:
Chowdhury, A.; Teferi, N.; Lee, S. J.; Vivanco-Suarez, J.; Chenoweth, D.; Littlefield, C. P.; Petronek, M.; Buatti, J. M.; Noeller, J.; Hitchon, P. W. Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience. Preprints2024, 2024020069. https://doi.org/10.20944/preprints202402.0069.v1
Chowdhury, A.; Teferi, N.; Lee, S. J.; Vivanco-Suarez, J.; Chenoweth, D.; Littlefield, C. P.; Petronek, M.; Buatti, J. M.; Noeller, J.; Hitchon, P. W. Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience. Preprints 2024, 2024020069. https://doi.org/10.20944/preprints202402.0069.v1
Chowdhury, A.; Teferi, N.; Lee, S. J.; Vivanco-Suarez, J.; Chenoweth, D.; Littlefield, C. P.; Petronek, M.; Buatti, J. M.; Noeller, J.; Hitchon, P. W. Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience. Preprints2024, 2024020069. https://doi.org/10.20944/preprints202402.0069.v1
APA Style
Chowdhury, A., Teferi, N., Lee, S. J., Vivanco-Suarez, J., Chenoweth, D., Littlefield, C. P., Petronek, M., Buatti, J. M., Noeller, J., & Hitchon, P. W. (2024). Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience. Preprints. https://doi.org/10.20944/preprints202402.0069.v1
Chicago/Turabian Style
Chowdhury, A., Jennifer Noeller and Patrick W Hitchon. 2024 "Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience" Preprints. https://doi.org/10.20944/preprints202402.0069.v1
Abstract
Background: The incidence of spinal metastatic disease has risen with improved cancer survivorship. Separation surgery, the current standard surgical treatment, does not fully address spinal deformity. Advances in operative management warrant reevaluating maximal tumor resection and anterior column reconstruction with corpectomy.
Methods: An IRB-approved retrospective single-center review of 63 patients was performed. Demographics, tumor characteristics, clinical and radiographic data, treatments, and neurological and survival outcomes were analyzed.
Results: The mean age at presentation was 63.5 ± 9.6 years (range, 37-84 years) and 28 patients (44.4%) were female. Functional outcomes, measured by KPS, RAND-36 survey scores and Oswestry Disability Index all improved postoperatively (pre- vs postop: 70 to 80 (p=0.0056), 26.5 to 46.4 (p=0.0081), and 28.9 to 16.9 (p=0.0613), respectively). Spinal alignment also improved, with Cobb angle measurements showing a reduction in spinal kyphosis from -5 to 0 (p=0.021). Nine patients (14.5%) had non-fatal postoperative complications. The median OS for this cohort was 14.4 months (range, 0.6-145.0 months) with median follow-up time of 15.5 months.
Conclusion: In oligometastatic spinal disease patients with good functional status, corpectomy for decompression of neural elements, deformity correction, and spinal stabilization is associated with improvements in pain and functional outcomes without overwhelming morbidity.
Medicine and Pharmacology, Oncology and Oncogenics
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