Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience

AJ Chowdhury
ORCID logo ,
Nahom Teferi
ORCID logo ,
Sarah J Lee
,
Juan Vivanco-Suarez
,
David Chenoweth
,
Connor P Littlefield
,
Michael Petronek
,
John M Buatti
,
Jennifer Noeller
,
Patrick W Hitchon
*
Version 1 : Received: 31 January 2024 / Approved: 1 February 2024 / Online: 1 February 2024 (12:58:00 CET)

How to cite: Chowdhury, A.; Teferi, N.; Lee, S.J.; Vivanco-Suarez, J.; Chenoweth, D.; Littlefield, C.P.; Petronek, M.; Buatti, J.M.; Noeller, J.; Hitchon, P.W. Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience. Preprints 2024, 2024020069. https://doi.org/10.20944/preprints202402.0069.v1 Chowdhury, A.; Teferi, N.; Lee, S.J.; Vivanco-Suarez, J.; Chenoweth, D.; Littlefield, C.P.; Petronek, M.; Buatti, J.M.; Noeller, J.; Hitchon, P.W. Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience. Preprints 2024, 2024020069. https://doi.org/10.20944/preprints202402.0069.v1

Abstract

Background: The incidence of spinal metastatic disease has risen with improved cancer survivorship. Separation surgery, the current standard surgical treatment, does not fully address spinal deformity. Advances in operative management warrant reevaluating maximal tumor resection and anterior column reconstruction with corpectomy. Methods: An IRB-approved retrospective single-center review of 63 patients was performed. Demographics, tumor characteristics, clinical and radiographic data, treatments, and neurological and survival outcomes were analyzed. Results: The mean age at presentation was 63.5 ± 9.6 years (range, 37-84 years) and 28 patients (44.4%) were female. Functional outcomes, measured by KPS, RAND-36 survey scores and Oswestry Disability Index all improved postoperatively (pre- vs postop: 70 to 80 (p=0.0056), 26.5 to 46.4 (p=0.0081), and 28.9 to 16.9 (p=0.0613), respectively). Spinal alignment also improved, with Cobb angle measurements showing a reduction in spinal kyphosis from -5 to 0 (p=0.021). Nine patients (14.5%) had non-fatal postoperative complications. The median OS for this cohort was 14.4 months (range, 0.6-145.0 months) with median follow-up time of 15.5 months. Conclusion: In oligometastatic spinal disease patients with good functional status, corpectomy for decompression of neural elements, deformity correction, and spinal stabilization is associated with improvements in pain and functional outcomes without overwhelming morbidity.

Keywords

Spinal metastasis; Corpectomy; Separation surgery; Kyphosis; Spinal oncology

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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