PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Association of White Matter T2 Hyper-Intense Signal in Fetal Brain Magnetic Resonance Imaging with Neurodevelopment of Fetuses with Cytomegalovirus Infection
Barkai, G.; Katorza, E.; Lassman, S.; Levinberg, I.; Hoffmann, C.; Bar-Yosef, O. Association between White Matter T2 Hyper-Intense Signals in Fetal Brain Magnetic Resonance Imaging and Neurodevelopment of Fetuses with Cytomegalovirus Infection. Diagnostics2024, 14, 797.
Barkai, G.; Katorza, E.; Lassman, S.; Levinberg, I.; Hoffmann, C.; Bar-Yosef, O. Association between White Matter T2 Hyper-Intense Signals in Fetal Brain Magnetic Resonance Imaging and Neurodevelopment of Fetuses with Cytomegalovirus Infection. Diagnostics 2024, 14, 797.
Barkai, G.; Katorza, E.; Lassman, S.; Levinberg, I.; Hoffmann, C.; Bar-Yosef, O. Association between White Matter T2 Hyper-Intense Signals in Fetal Brain Magnetic Resonance Imaging and Neurodevelopment of Fetuses with Cytomegalovirus Infection. Diagnostics2024, 14, 797.
Barkai, G.; Katorza, E.; Lassman, S.; Levinberg, I.; Hoffmann, C.; Bar-Yosef, O. Association between White Matter T2 Hyper-Intense Signals in Fetal Brain Magnetic Resonance Imaging and Neurodevelopment of Fetuses with Cytomegalovirus Infection. Diagnostics 2024, 14, 797.
Abstract
An association between subtle changes in T2 white matter hyper-intense signals (WMHS) de-tected in fetal brain magnetic resonance imaging (fbMRI) and congenital cytomegalovirus (CMV) infection has been established. The research aim of this study is to compare children with congenital CMV infection with neurodevelopment outcome and hearing deficit with and with-out WMHS in a prospective historic cohort of 58 fbMRIs. Of these, WMHS was detected in 21. The median infection week of the WMHS group was earlier than the normal fbMRI group (8 and 17 weeks of gestation respectively). The proportion of infants treated with valganciclovir in the WMHS group was distinctly higher. Hearing impairment was not significantly different be-tween the groups. VABS scores in all 4 domains were within normal range in both groups. The median score of the motor skills corrected for week of infection was better in the WMHS group. A multivariate analysis using week of infection interaction variable of WMHS and valganciclo-vir treatment showed better motor score outcomes in the valganciclovir treatment group despite earlier week of infection. WMHS was not associated with neurodevelopmental outcome and hearing deficit. In our cohort valganciclovir treatment may have a protective effect on fetuses with WMHS by improving neurodevelopment outcome.
Keywords
Fetus; Brain; Magnetic Resonance Imaging; Cytomegalovirus; White matter
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
