Version 1
: Received: 30 January 2024 / Approved: 31 January 2024 / Online: 31 January 2024 (12:53:20 CET)
How to cite:
Rong, G.; Kavokin, A.; Sawan, M. Optical Biosensor Based on Porous Silicon and Tamm Plasmon Polariton for Detection of CagA Antigen of Helicobacter Pylori. Preprints2024, 2024012192. https://doi.org/10.20944/preprints202401.2192.v1
Rong, G.; Kavokin, A.; Sawan, M. Optical Biosensor Based on Porous Silicon and Tamm Plasmon Polariton for Detection of CagA Antigen of Helicobacter Pylori. Preprints 2024, 2024012192. https://doi.org/10.20944/preprints202401.2192.v1
Rong, G.; Kavokin, A.; Sawan, M. Optical Biosensor Based on Porous Silicon and Tamm Plasmon Polariton for Detection of CagA Antigen of Helicobacter Pylori. Preprints2024, 2024012192. https://doi.org/10.20944/preprints202401.2192.v1
APA Style
Rong, G., Kavokin, A., & Sawan, M. (2024). Optical Biosensor Based on Porous Silicon and Tamm Plasmon Polariton for Detection of CagA Antigen of <em>Helicobacter Pylori</em>. Preprints. https://doi.org/10.20944/preprints202401.2192.v1
Chicago/Turabian Style
Rong, G., Alexey Kavokin and Mohamad Sawan. 2024 "Optical Biosensor Based on Porous Silicon and Tamm Plasmon Polariton for Detection of CagA Antigen of <em>Helicobacter Pylori</em>" Preprints. https://doi.org/10.20944/preprints202401.2192.v1
Abstract
Helicobacter Pylori (H. Pylori) is a common pathogen with high prevalence of infection in human populations. Diagnosis of H. Pylori infection is critical for its treatment, eradication, and prognosis. Biosensors have been demonstrated to be powerful for rapid onsite detection of pathogens, particularly for point-of-care test (POCT) scenarios. In this work, we propose a novel optical biosensor, based on nanomaterial porous silicon (PSi) and photonic surface state Tamm Plasmon Polariton (TPP), for detection of cytotoxin-associated antigen A (CagA) antigen of H. Pylori bacterium. We fabricated the PSi TPP biosensor, analysed its optical characteristics and demonstrated through experiments towards sensing of CagA antigen, that TPP biosensor has sensitivity of 100 pm/(ng/ml), limit of detection of 0.01 ng/ml, and specificity in terms of positive-to-negative ratio of more than six. From these performance factors, it can be concluded that TPP biosensor can serve as an effective tool for diagnosis of H. Pylori infection, either in analytical labs or in POCT applications.
Keywords
Optical Biosensor; Tamm Plasmon Polariton; Porous Silicon; CagA antigen; Helicobacter Pylori; High Sensitivity; Specificity; Disgnostics
Subject
Engineering, Electrical and Electronic Engineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
