Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effects of Premature Ventrıcular Complex Burden on Left Ventrıcular Global Longıtudınal Straın in Patıents Wıthout Structural Heart Dısease

Sukru Arslan
ORCID logo ,
H. Ozan Arabaci
* ORCID logo ,
Muhammed Furkan Deniz
,
Mehmet Emin Gokce
,
Seyma Arslan
,
Veysel Oktay
ORCID logo ,
Mustafa Yildiz
,
Isil Uzunhasan
Version 1 : Received: 29 January 2024 / Approved: 29 January 2024 / Online: 29 January 2024 (13:05:48 CET)

A peer-reviewed article of this Preprint also exists.

Sukru, A.; Ozan, A.H.; Furkan, D.M.; Emin, G.M.; Seyma, A.; Veysel, O.; Mustafa, Y.; Isıl, U. Effects of Premature Ventricular Complex Burden on Left Ventricular Global Longitudinal Strain in Patients without Structural Heart Disease. J. Clin. Med. 2024, 13, 1796. Sukru, A.; Ozan, A.H.; Furkan, D.M.; Emin, G.M.; Seyma, A.; Veysel, O.; Mustafa, Y.; Isıl, U. Effects of Premature Ventricular Complex Burden on Left Ventricular Global Longitudinal Strain in Patients without Structural Heart Disease. J. Clin. Med. 2024, 13, 1796.

Abstract

Background: Evaluation of left ventricular(LV) functions in patients with idiopathic premature ventricular contraction(PVC) with preserved LV Ejection Fraction(LVEF), especially in the subclinical stage, may be of great importance in terms of directing early treatment. Methods: A total of 122 patients, retrospectively recruited, were divided into three groups according to PVC burden: Group 1; 5%PVC<10%, Group 2; 10%PVC<15%, and Group 3; 15% PVC. Transthoracic echocardiography(TTE) was performed to evaluate LV parameters. Results: LV-GLS was found to be significantly lower in groups 2 and 3 with high PVC burden (18.89 ± 1.4, 17.55 ± 2.1, 16.26 ± 1.3; p<0.001 respectively). Correlation analysis revealed a positive and significant correlation between PVC burden with deterioration in LV-GLS (r:0.536; p<0.001). In addition, PVC burden was found to be an independent predictor of LV-GLS deterioration in multiple linear regression analysis(:0.525, p<0.001). The ROC curve analysis demonstrated that a PVC burden cut-off value of 8.4% was associated with a LV-GLS deterioration greater than -18, with a specificity of 75.4% and a sensitivity of 75.4% (AUC: 0.81 [0.73-0.88] 95% CI; p<0.001). Conclusions: PVC burden was an independent predictor of deterioration in LV-GLS. In the presence of subclinical LV injury associated with PVC burden, early catheter ablation strategies may be therapeutically beneficial.

Keywords

idiopathic PVC; global longitudinal strain; PVC burden

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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