Version 1
: Received: 26 January 2024 / Approved: 26 January 2024 / Online: 29 January 2024 (02:11:05 CET)
How to cite:
BASU, A.; GHOSH, A.; Dolui, B.; Majumdar, B.; Krishna, P.; Bandopadhaya, A. TIM3 or HAVCR2 in Breast Cancer Instead of Suppression May Invoke Immune Action in Tumor Micro Environment. Preprints2024, 2024011916. https://doi.org/10.20944/preprints202401.1916.v1
BASU, A.; GHOSH, A.; Dolui, B.; Majumdar, B.; Krishna, P.; Bandopadhaya, A. TIM3 or HAVCR2 in Breast Cancer Instead of Suppression May Invoke Immune Action in Tumor Micro Environment. Preprints 2024, 2024011916. https://doi.org/10.20944/preprints202401.1916.v1
BASU, A.; GHOSH, A.; Dolui, B.; Majumdar, B.; Krishna, P.; Bandopadhaya, A. TIM3 or HAVCR2 in Breast Cancer Instead of Suppression May Invoke Immune Action in Tumor Micro Environment. Preprints2024, 2024011916. https://doi.org/10.20944/preprints202401.1916.v1
APA Style
BASU, A., GHOSH, A., Dolui, B., Majumdar, B., Krishna, P., & Bandopadhaya, A. (2024). TIM3 or HAVCR2 in Breast Cancer Instead of Suppression May Invoke Immune Action in Tumor Micro Environment. Preprints. https://doi.org/10.20944/preprints202401.1916.v1
Chicago/Turabian Style
BASU, A., Pallavi Krishna and Arghya Bandopadhaya. 2024 "TIM3 or HAVCR2 in Breast Cancer Instead of Suppression May Invoke Immune Action in Tumor Micro Environment" Preprints. https://doi.org/10.20944/preprints202401.1916.v1
Abstract
Immune checkpoint receptors play a crucial role in steering tumor progression, prompting a focused investigation into the role of TIM3 in breast cancer. Analysis of TCGA BRCA data unveiled diverse correlations between TIM-3 expression and immune cell infiltration across subtypes. In our in-house cohort studied through IHC, significant changes in TIM3 expression with tumor grades were observed. Higher TIM3 expression correlated with increased disease-free survival in pan breast cancer, marking the first revelation of TIM3's positive role in pan BC prognosis. The study indicates that alluring TIM3 response, rather than suppression, may enhance breast cancer prognosis.
Keywords
Breast Cancer;Triple negative breast cancer; T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3); HAVCR-2; TCGA; BRCA; TIMER2.0; UALCAN; GEPIA
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
