Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Design of a Remote Time-Restricted Eating and Mindfulness Intervention to Reduce Risk Factors Associated with Early-Onset Colorectal Cancer Development among Young Adults

Manoela Lima Oliveira
* ORCID logo ,
Alana Biggers
,
Vanessa M Oddo
ORCID logo ,
Keith B Naylor
,
Zhengjia (Nelson) Chen
ORCID logo ,
Alyshia Hamm
,
Lacey Pezley
ORCID logo ,
Beatriz Peñalver Bernabé
,
Kelsey Gabel
ORCID logo ,
Lisa K Sharp
,
Lisa Marie Tussing-Humphreys
*
Version 1 : Received: 24 January 2024 / Approved: 25 January 2024 / Online: 26 January 2024 (06:55:36 CET)

A peer-reviewed article of this Preprint also exists.

Lima Oliveira, M.; Biggers, A.; Oddo, V.M.; Naylor, K.B.; Chen, Z.; Hamm, A.; Pezley, L.; Peñalver Bernabé, B.; Gabel, K.; Sharp, L.K.; Tussing-Humphreys, L.M. Design of a Remote Time-Restricted Eating and Mindfulness Intervention to Reduce Risk Factors Associated with Early-Onset Colorectal Cancer Development among Young Adults. Nutrients 2024, 16, 504. Lima Oliveira, M.; Biggers, A.; Oddo, V.M.; Naylor, K.B.; Chen, Z.; Hamm, A.; Pezley, L.; Peñalver Bernabé, B.; Gabel, K.; Sharp, L.K.; Tussing-Humphreys, L.M. Design of a Remote Time-Restricted Eating and Mindfulness Intervention to Reduce Risk Factors Associated with Early-Onset Colorectal Cancer Development among Young Adults. Nutrients 2024, 16, 504.

Abstract

Early-onset colorectal cancer (EOCRC) is defined as a diagnosis of colorectal cancer (CRC) in individuals younger than 50 years of age. While overall CRC rates in the United States (US) decreased between 2001 and 2018, EOCRC rates have increased. This research project aims to evaluate the feasibility and acceptability of Time-Restricted Eating (TRE), Mindfulness, or TRE combined with Mindfulness among young to middle-aged adults at risk of EOCRC. Forty-eight participants will be randomly assigned to one of four groups: TRE, Mindfulness, TRE & Mindfulness, or Control. Data on feasibility, adherence, and acceptability will be collected. Measures assessed at baseline and post-intervention will include body weight, body composition, dietary intake, physical activity, sleep behavior, circulating biomarkers, hair cortisol, and gut microbiome. Effects of the intervention on the following will be examined: 1) acceptability and feasibility; 2) body weight, body composition, and adherence to TRE; 3) circulating metabolic, inflammation, and oxidative stress biomarkers; 4) intestinal inflammation; and 5) the gut microbiome. TRE combined with Mindfulness holds promise for stress reduction and weight management among individuals at risk of EOCRC. The results of this pilot study will inform the design and development of larger trials aimed at preventing risk factors associated with EOCRC.

Keywords

time-restricted eating; mindfulness; early-onset colorectal cancer; feasibility; acceptability; stress reduction; weight management

Subject

Biology and Life Sciences, Behavioral Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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