Que, H.; Mai, E.; Hu, Y.; Li, H.; Zheng, W.; Jiang, Y.; Han, F.; Li, X.; Gong, P.; Gu, J. Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair. Preprints2024, 2024011844. https://doi.org/10.20944/preprints202401.1844.v1
APA Style
Que, H., Mai, E., Hu, Y., Li, H., Zheng, W., Jiang, Y., Han, F., Li, X., Gong, P., & Gu, J. (2024). Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair. Preprints. https://doi.org/10.20944/preprints202401.1844.v1
Chicago/Turabian Style
Que, H., Puyang Gong and Jian Gu. 2024 "Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair" Preprints. https://doi.org/10.20944/preprints202401.1844.v1
Abstract
Multilineage-differentiating stress-enduring (Muse) cells, a cell subgroup from mesenchymal stem cells (MSCs), are pluripotent cells with unique characteristics such as non-tumorigenic and pluripotent differentiation ability. After homing, Muse cells spontaneously differentiate into tissue component cells and supplement damaged/lost cells to participate in tissue repair. Importantly, Muse cells can survive in injured tissue for an extended period, stabilizing and promoting tissue repair. In addition, it has been confirmed that injection of exogenous Muse cells exerts anti-inflammatory, anti-apoptosis, anti-fibrosis, immunomodulatory, and paracrine protective effects in vivo. The discovery of Muse cells is an important breakthrough in regenerative medicine. The article provides a comprehensive review of the characteristics, sources, and potential mechanisms of Muse cells for tissue repair and regeneration. This review serves as a foundation for the further utilization of Muse cells as a key clinical tool in regenerative medicine.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
