Sid Ahmed, M.A.; Hamid, J.M.; Hassan, A.M.M.; Abu Jarir, S.; Bashir Ibrahim, E.; Abdel Hadi, H. Phenotypic and Genotypic Characterization of Pan-Drug-Resistant Klebsiella pneumoniae Isolated in Qatar. Antibiotics2024, 13, 275.
Sid Ahmed, M.A.; Hamid, J.M.; Hassan, A.M.M.; Abu Jarir, S.; Bashir Ibrahim, E.; Abdel Hadi, H. Phenotypic and Genotypic Characterization of Pan-Drug-Resistant Klebsiella pneumoniae Isolated in Qatar. Antibiotics 2024, 13, 275.
Sid Ahmed, M.A.; Hamid, J.M.; Hassan, A.M.M.; Abu Jarir, S.; Bashir Ibrahim, E.; Abdel Hadi, H. Phenotypic and Genotypic Characterization of Pan-Drug-Resistant Klebsiella pneumoniae Isolated in Qatar. Antibiotics2024, 13, 275.
Sid Ahmed, M.A.; Hamid, J.M.; Hassan, A.M.M.; Abu Jarir, S.; Bashir Ibrahim, E.; Abdel Hadi, H. Phenotypic and Genotypic Characterization of Pan-Drug-Resistant Klebsiella pneumoniae Isolated in Qatar. Antibiotics 2024, 13, 275.
Abstract
At secondary healthcare, Carbapenem-Resistant Enterobacterales (CREs) such as observed in Klebsiella pneumoniae are a global public health priority with significant clinical outcomes. In this study, we describe clinical, phenotypic, and genotypic characteristics of three pan-drug resistant (PDR) isolates that demonstrated extended resistance to conventional and novel antimicrobials. All patients had risk factors for acquisition of multidrug resistant organisms while microbiological susceptibility testing showed resistance to all conventional antimicrobials. Advanced susceptibility testing demonstrated resistance to broad agents such as ceftazidime-avibactam, ceftolozane-tazobactam, and meropenem-vaborbactam. Nevertheless, all isolates were susceptible to cefiderocol, one of the novel antimicrobials that demonstrated potent in vitro activity against resistant Gram-negative bacteria including CREs pointing towards potential therapeutic role for PDR pathogens. Expanded genomic studies revealed multiple antimicrobial resistant genes (ARGs), including blaNMD-5 and blaOXA derivative types as well as a mutated outer membrane porin protein (OmpK37).
Keywords
AMR GNB Klebsiella pneumoniae
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
