Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of Imaging in Cervical Cancer Staging – ESGO/ESTRO/ESP Guidelines (Update 2023)

Version 1 : Received: 22 January 2024 / Approved: 23 January 2024 / Online: 24 January 2024 (07:21:52 CET)

A peer-reviewed article of this Preprint also exists.

Fischerova, D.; Frühauf, F.; Burgetova, A.; Haldorsen, I.S.; Gatti, E.; Cibula, D. The Role of Imaging in Cervical Cancer Staging: ESGO/ESTRO/ESP Guidelines (Update 2023). Cancers 2024, 16, 775. Fischerova, D.; Frühauf, F.; Burgetova, A.; Haldorsen, I.S.; Gatti, E.; Cibula, D. The Role of Imaging in Cervical Cancer Staging: ESGO/ESTRO/ESP Guidelines (Update 2023). Cancers 2024, 16, 775.

Abstract

Following the European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) joint guide-lines (2018) for the management of patients with cervical cancer, treatment decisions should be guided by modern imaging techniques. After five years (2023), an update of the ES-GO-ESTRO-ESP recommendations was performed furtherly confirming this statement. Trans-vaginal/transrectal ultrasound (TRS/TVS) or pelvic magnetic resonance (MRI) enables tumour delineation and precise assessment of its local extent, including the evaluation of the depth of infiltration in the bladder- or rectal wall. Additionally, both techniques have very high specificity to confirm the presence of metastatic pelvic lymph nodes but fail to exclude them due to insuffi-cient sensitivity to detect small-volume metastases, as any other currently available imaging modality. In early-stage disease (T1a to T2a1, except T1b3) with negative lymph nodes on TVS/TRS or MRI, surgicopathological staging should be performed. In all other situations, con-trast-enhanced computed tomography (CECT) or 18F-fluorodeoxyglucose positron emission tomography in combination with CT (PET-CT) are recommended to assess extrapelvic spread. The aim of this paper is to review the evidence supporting the implementation of diagnostic imaging with a focus on ultrasound at primary diagnostic workup of cervical cancer.

Keywords

cervical cancer; staging; ultrasound; MRI; CT; PET-CT; neoplasm; diagnostic imaging

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

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