Review
Version 1
Preserved in Portico This version is not peer-reviewed
Vaccination-Associated Pathogenesis
Version 1
: Received: 23 January 2024 / Approved: 23 January 2024 / Online: 23 January 2024 (11:13:33 CET)
How to cite: Chang, C.; Chi, C.Y.; Yang, C.; Hsu, S. Vaccination-Associated Pathogenesis. Preprints 2024, 2024011689. https://doi.org/10.20944/preprints202401.1689.v1 Chang, C.; Chi, C.Y.; Yang, C.; Hsu, S. Vaccination-Associated Pathogenesis. Preprints 2024, 2024011689. https://doi.org/10.20944/preprints202401.1689.v1
Abstract
Vaccination represents the historical milestone in medical sciences, which has been saving millions of lives. Nonetheless, continued outbreaks of emergent infectious diseases are swamping from every coast to every border all over the world. Modern vaccines are our most powerful arsenals to defend the public health of a global population ever since 1796. As unexpected, modern vaccination approaches have brought out all sorts of unwelcome pathogenic disorders to varying extents. Pathogenic viruses have also continued to evolve to defeat elaborate arsenals devised by human intelligence. In this review, we have covered a variety of vaccination approaches along with their sophisticated materials from the past to the most recent development. Furthermore, we discuss varied serious pathogenic outcomes elicited by contemporary vaccination programmes involving novel materials in real clinical trials. The complex immune mediators will be discussed in the context to tackle the complication of vaccine-induced pathogenesis. We will offer the insight into the intractable discrepancy of vaccine-associated pathology. The precision approach bestowed with evolutionary concepts will be considered as a feasible option to confront various issues of pathogenic complicacy.
Keywords
vaccine; pathogenesis; viruses; evolution; adjuvant; precision medicine
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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