Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson’s Disease

Carla Silva-Batista
* ORCID logo ,
Jumes Lira
,
Daniel Boari Coelho
,
Andrea Lima-Pardini
,
Mariana Nucci
,
Eugenia Mattos
,
Fernando Henrique Magalhães
ORCID logo ,
Egberto Barbosa
,
Luis Teixeira
,
Edson Amaro Jr
,
Carlos Ugrinowitsch
,
Fay B. Horak
ORCID logo
Version 1 : Received: 18 January 2024 / Approved: 22 January 2024 / Online: 23 January 2024 (13:44:14 CET)

A peer-reviewed article of this Preprint also exists.

Silva-Batista, C.; Lira, J.; Coelho, D.B.; de Lima-Pardini, A.C.; Nucci, M.P.; Mattos, E.C.T.; Magalhaes, F.H.; Barbosa, E.R.; Teixeira, L.A.; Amaro Junior, E.; Ugrinowitsch, C.; Horak, F.B. Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson’s Disease. Brain Sci. 2024, 14, 178. Silva-Batista, C.; Lira, J.; Coelho, D.B.; de Lima-Pardini, A.C.; Nucci, M.P.; Mattos, E.C.T.; Magalhaes, F.H.; Barbosa, E.R.; Teixeira, L.A.; Amaro Junior, E.; Ugrinowitsch, C.; Horak, F.B. Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson’s Disease. Brain Sci. 2024, 14, 178.

Abstract

Individuals with Parkinson’s disease (PD) and freezing of gait (FOG) have a loss of presynaptic inhibition (PSI) during anticipatory postural adjustments (APAs) for step initiation. The mesencephalic locomotor region (MRL) has connections to the reticulospinal tract that mediates inhibitory interneurons responsible for modulating PSI and APAs. Here, we hypothesized that MLR activity during step initiation would explain the loss of PSI during APAs for step initiation in freezers. Thirty-four freezers were assessed in the ON-medication state. During a functional magnetic resonance imaging protocol of simulated APA task, we assessed beta of blood oxygenation level-dependent signal change of areas known to initiate and pace gait (e.g., MLR), in addition to PSI of the soleus muscle during APA for step initiation, and clinical (e.g., disease duration) and behavioral (e.g., FOG severity and APAs amplitude for step initiation) variables. A linear multiple regression model showed that MLR activity (R2=0.32, P=0.0006) and APA amplitude (R2=0.13, P=0.0097) explained together 45% of the loss of PSI during step initiation in freezers. Decreased MLR activity during a simulated APA task is related to a higher loss of PSI during APA for step initiation. Deficits in central and spinal inhibitions during APA may be related to FOG pathophysiology.

Keywords

Mesencephalic locomotor region; Anticipatory Postural Adjustment; Presynaptic inhibition; Freezers; Step initiation; H-reflex

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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