Li, J.; Wang, X.; Wu, X. Molecular Mechanisms of Nuclear Import of Baculovirus Proteins. Preprints2024, 2024011611. https://doi.org/10.20944/preprints202401.1611.v1
APA Style
Li, J., Wang, X., & Wu, X. (2024). Molecular Mechanisms of Nuclear Import of Baculovirus Proteins. Preprints. https://doi.org/10.20944/preprints202401.1611.v1
Chicago/Turabian Style
Li, J., Xing-Yang Wang and Xiao-Feng Wu. 2024 "Molecular Mechanisms of Nuclear Import of Baculovirus Proteins" Preprints. https://doi.org/10.20944/preprints202401.1611.v1
Abstract
Baculovirus is a type of virus with a double stranded, circular, and super helical DNA structure, whose transcription, replication and assembly of offspring virus occur in the nucleus of the cell. However, due to the natural barrier of the cellular nuclear membrane, macromolecular substances larger than 40-60 kDa cannot directly penetrate the nuclear membrane. Therefore, baculovirus have evolved various strategies to achieve transmembrane transport of viral proteins. This article attempts to review the recent literature on mechanisms by which the DNA baculoviruses of insects transport proteins into the infected host cell nucleus. In this article, we summarise the studies of nuclear localisation signals(NLSs) in baculovirus, which are involved in the classical nuclear import pathways and review the non-classical nuclear transport pathways independent on NLS derived from baculovirus. Moreover, during the protein nuclear transport process, viruses will regulate the nuclear pathway through protein modifications. Host structure changes and other methods will create a favorable environment for the nuclear transport of viral proteins.
Keywords
Baculovirus; Nuclear location signal; Nuclear transport receptors; Nuclear pore complex; Protein modification
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
