Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Genome and Epigenome Disorders and Male Infertility: Feedback from 15 Years of Clinical and Research Experience

Benkhalifa Moncef
* ,
Debbie Montjean
* ORCID logo ,
Marion Beaumont
,
Abdelhafid Natiq
,
Noureddine Louanjli
,
André Hazout
,
Pierre Miron
ORCID logo ,
Thomas Liehr
,
Cabry Rosalie
,
Ilham Ratbi
Version 1 : Received: 19 January 2024 / Approved: 22 January 2024 / Online: 22 January 2024 (09:00:32 CET)

A peer-reviewed article of this Preprint also exists.

Montjean, D.; Beaumont, M.; Natiq, A.; Louanjli, N.; Hazout, A.; Miron, P.; Liehr, T.; Cabry, R.; Ratbi, I.; Benkhalifa, M. Genome and Epigenome Disorders and Male Infertility: Feedback from 15 Years of Clinical and Research Experience. Genes 2024, 15, 377. Montjean, D.; Beaumont, M.; Natiq, A.; Louanjli, N.; Hazout, A.; Miron, P.; Liehr, T.; Cabry, R.; Ratbi, I.; Benkhalifa, M. Genome and Epigenome Disorders and Male Infertility: Feedback from 15 Years of Clinical and Research Experience. Genes 2024, 15, 377.

Abstract

Infertility is affecting around 20 % of couples in the age of procreation but however in some societies as many as one-third of all couples are unable to conceive. Different factors are contributing to male fertility declining such us endocrine disruptors environmental and professional exposures, oxidative stress and life style changes with risks of de novo epigenetics dysregulation. Since the fantastic development of new technologies of Omes and Omics , the contribution of inherited or de novo genomes and epigenome disorders contributions in male infertility are more elucidated and relevant. More than somatic genome investigation of infertile men (from chromosome to single or multiple gene point mutations) many others techniques become available in molecular andrology laboratory to investigate the genome and epigenome integrity, the maturation and the competency of the spermatozoa and its physiological environment. All those new methods of assessment are demonstrating the role of genetics and epigenetics disorders contribution on reproductive pathology and are helping the professional of assisted reproductive technology to propose different management strategy of male infertility to improve the clinical outcomes and minimize the risk of genetics or metabolic disorders at birth.

Keywords

Male infertility; genome and epigenome disorders

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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