Molecular Targeting of the Claudins Pathway.

Caroline Hana; Nyein Nyein Thaw Dar; Michael Galo Venegas; Michel Vulfovich

doi:10.20944/preprints202401.1546.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 20 January 2024 / Approved: 22 January 2024 / Online: 22 January 2024 (10:02:04 CET)

Claudins are a family of 27 proteins that have an important role in the formation of tight junc-tions. They also have an important function in ions exchange, cell mobility, and in in the epitheli-al-to-mesenchymal transition, the latter being very important in cancer invasion and metastasis. Therapeutic targeting of claudins has been investigated to improve cancer outcomes. Recent evi-dence shows improved outcomes when combining monoclonal antibodies against Claudin 18.2 with chemotherapy for patients with gastroesophageal junction cancer. Currently Chimeric anti-gen receptor T-cells targeting Claudin 18 are under investigation.

Claudin; monoclonal antibodies; adenocarcinoma; targeted therapy; CAR-T cell therapy

Medicine and Pharmacology, Oncology and Oncogenics

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Molecular Targeting of the Claudins Pathway.

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