Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Comparison of LIRADS 5 Image Guided Core Biopsy Derived From Formalin Fixed and Frozen Tissue Cores for Radiogenomics and Radioproteomics Analysis in Well, Moderate and Poorly Differentiated Hepatocellular Carcinoma

Margaret Simonian
* ,
David sk Lu
,
Julian P Whitelegge
ORCID logo ,
Whitaker Cohn
,
Preeti Ahuja
,
William Hsu
,
Steven Raman
Version 1 : Received: 19 January 2024 / Approved: 19 January 2024 / Online: 19 January 2024 (10:51:19 CET)

How to cite: Simonian, M.; Lu, D.S.; Whitelegge, J.P.; Cohn, W.; Ahuja, P.; Hsu, W.; Raman, S. Comparison of LIRADS 5 Image Guided Core Biopsy Derived From Formalin Fixed and Frozen Tissue Cores for Radiogenomics and Radioproteomics Analysis in Well, Moderate and Poorly Differentiated Hepatocellular Carcinoma. Preprints 2024, 2024011491. https://doi.org/10.20944/preprints202401.1491.v1 Simonian, M.; Lu, D.S.; Whitelegge, J.P.; Cohn, W.; Ahuja, P.; Hsu, W.; Raman, S. Comparison of LIRADS 5 Image Guided Core Biopsy Derived From Formalin Fixed and Frozen Tissue Cores for Radiogenomics and Radioproteomics Analysis in Well, Moderate and Poorly Differentiated Hepatocellular Carcinoma. Preprints 2024, 2024011491. https://doi.org/10.20944/preprints202401.1491.v1

Abstract

The aim of this pilot study is to evaluate and compare the quality of the genomics and proteomics data obtained from paired formalin fixed paraffin embedded (FFPE) and frozen (FF) tissue percutaneous core biopsies of LIRADS 5 hepatocellular carcinoma (HCC) of varying histological grade. The preliminary data identified differentially expressed proteins and genes in poor, moderate and well differentiated HCC biopsies, with a greater efficacy in fresh frozen samples.

Keywords

Liver HCC, radioproteomics, radiogenomics

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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