Salam, M.T.; Bari, K.F.; Gafur, D.M.M.; Faruk, M.O.; Akter, K.; shaikat, T.A.; Das, A.C.; Tofayel, M.; Mithun, M.H.; Sunny, A.R. Antibiotic Resistance Pattern in Intensive Care Unit Patients of Bangladesh. Preprints2024, 2024011277. https://doi.org/10.20944/preprints202401.1277.v1
APA Style
Salam, M.T., Bari, K.F., Gafur, D.M.M., Faruk, M.O., Akter, K., shaikat, T.A., Das, A.C., Tofayel, M., Mithun, M.H., & Sunny, A.R. (2024). Antibiotic Resistance Pattern in Intensive Care Unit Patients of Bangladesh. Preprints. https://doi.org/10.20944/preprints202401.1277.v1
Chicago/Turabian Style
Salam, M.T., Mahmudul Hasan Mithun and Atiqur Rahman Sunny. 2024 "Antibiotic Resistance Pattern in Intensive Care Unit Patients of Bangladesh" Preprints. https://doi.org/10.20944/preprints202401.1277.v1
Abstract
The fate of critically sick patients with infections in intensive care units (ICUs) is significantly influenced by antimicrobial resistance, which has become a serious concern in developing nations. This observational study was conducted at the IBN Sina Specialised Hospital in Dhaka, Bangladesh, over a 12-month period from January 2021 to December 2021, in order to track the pattern of antibiotic resistance among the patients admitted to the intensive care unit (ICU). Aspiration pneumonia (29%) and diabetes mellitus (24%), among 200 patients, were the most common main diagnoses. 65 samples (or 26%) of the 250 samples had 85 bacteria identified from them. Urine (14.12%) and tracheal aspirate (64.71%) were the most frequently found sites of infection. In the sample from the tracheal aspirate, Pseudomonas spp. (30.59%), Escherichia coli (24.71%), Acinetobacter spp. (20%), and Klebsiella spp. (14.12) were the most frequently isolated microorganisms. The following antibiotics were shown to have the highest overall patterns of resistance: levofloxacin (68.24), amikacin (64.71), meropenem (49.41), ceftazidime (75.29), ciprofloxacin (78.82), and gentamicin (82.35). The most effective antibiotic against Klebsiella species was meropenem (64.61%), while Acinetobacter species were mostly susceptible to cotrimoxazole (64.67%) and piperacillin + tazobactam (60.50%). Most susceptible to netilmicin (70.48%) and meropenem (49.32%) were Escherichia coli, while Pseudomonas spp. were mostly responsive to colistin (55.14%) and netilmicin (52.25%). Antibiotic resistance is common among intensive care unit (ICU) patients, and most isolated microbes have resistance to traditional medicines.
Keywords
Resistance to antibiotics; ICU; Pneumonia.; Diabetes; Infection; Bangladesh
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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