Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Connecting the Dots: AfrAbia's Environmental Challenges and Parkinson's Disease

Version 1 : Received: 13 January 2024 / Approved: 16 January 2024 / Online: 16 January 2024 (06:29:16 CET)

How to cite: Mohamed, W.M.Y. Connecting the Dots: AfrAbia's Environmental Challenges and Parkinson's Disease. Preprints 2024, 2024011168. https://doi.org/10.20944/preprints202401.1168.v1 Mohamed, W.M.Y. Connecting the Dots: AfrAbia's Environmental Challenges and Parkinson's Disease. Preprints 2024, 2024011168. https://doi.org/10.20944/preprints202401.1168.v1

Abstract

Background: Parkinson's disease (PD) is a global disease. However, there is a lack of research specifically focused on the AfrAbia population. Climate change, driven mainly by global warming, is linked to detrimental health impacts, including an increased frequency and intensity of heat waves. Neurological diseases, including neurodegenerative syndromes like Alzheimer's disease, Parkinson's disease, and motor neuron illnesses, have been increasingly seen and recorded in scientific literature. Although there is much literature demonstrating the growth in neurodegenerative disorders, the relationship between environmental variables such as global warming, air pollution, heavy metals, and pesticides and the higher occurrence of these illnesses is still unknown. Objective: The current article primarily aims to examine the relationship between climatic changes, air pollution, pesticides, heavy metals, and the occurrence of PD. Initially, we evaluate the influence of exposure to these variables on the cause or origin of Parkinson's disease. In addition, we will investigate how these variables disrupt processes such as excitotoxicity, oxidative stress, and neuroinflammation, all of which are strongly linked to Parkinson's disease (PD). Conclusions: This research presents a plausible rationale for the adverse effects of environmental influences on the brain, which are pivotal in the progression or onset of Parkinson's disease from an AfrAbian standpoint.

Keywords

AfrAbia; Parkinson’s Disease; Global warming; Malathion; Air pollution; Heavy metals

Subject

Medicine and Pharmacology, Neuroscience and Neurology

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