Edelman, M.; Slavin, J.; Wang, Q. The Dose Response Effects of Partially Hydrolyzed Guar Gum on Gut Microbiome of Healthy Adults. Journal of the Academy of Nutrition and Dietetics 2023, 123, A38, doi:10.1016/j.jand.2023.06.130.
Edelman, M.; Slavin, J.; Wang, Q. The Dose Response Effects of Partially Hydrolyzed Guar Gum on Gut Microbiome of Healthy Adults. Journal of the Academy of Nutrition and Dietetics 2023, 123, A38, doi:10.1016/j.jand.2023.06.130.
Edelman, M.; Slavin, J.; Wang, Q. The Dose Response Effects of Partially Hydrolyzed Guar Gum on Gut Microbiome of Healthy Adults. Journal of the Academy of Nutrition and Dietetics 2023, 123, A38, doi:10.1016/j.jand.2023.06.130.
Edelman, M.; Slavin, J.; Wang, Q. The Dose Response Effects of Partially Hydrolyzed Guar Gum on Gut Microbiome of Healthy Adults. Journal of the Academy of Nutrition and Dietetics 2023, 123, A38, doi:10.1016/j.jand.2023.06.130.
Abstract
Background: Partially hydrolyzed guar gum (PHGG) is a water-soluble, prebiotic fiber that is used in foods and supplements. The effects of PHGG and its role in gut health are still being studied. The purpose of this study was to evaluate changes in the gut microbiome composition of healthy individuals in response to low-dose PHGG supplementation compared with a low fiber diet. Methods: A randomized, double-blind, placebo-controlled crossover study was performed on 33 healthy subjects (17 male, 16 female). Each subject completed three 14-day treatment periods with a 2-week washout between each period. Treatments included supplementation with 3 g PHGG, 6 g PHGG, or placebo. During all periods, the participants followed a low fiber diet (<14 g/day). Stools were collected on days 0 and 14 of each period. Gut microbiome profiling was performed using 16S rRNA sequencing. Results: Supplementation of 3 g and 6 g PHGG significantly increased Verrucomicrobia on day 14 when compared to the placebo (p=0.0066 and p= 0.0068, respectively). On the genus level, Akkermansia was significantly increased on day 14 with both the 3 g and 6 g PHGG doses (p=0.0081 and p=0.0083). Faecalibacterium was significantly decreased on day 14 with 3 g PHGG (p=0.0054). Conclusion: Supplementing with low doses of PHGG has the potential to cause shifts in gut microbiome composition. By increasing beneficial microbes, PHGG can improve the microbiome composition of healthy individuals and may play a role in the treatment of inflammatory gastrointestinal diseases.
Keywords
dietary fiber; PHGG; gut microbiome; soluble dietary fiber
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
