Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Nutrient Intake and its Association with Appendicular Total Lean Mass, Function and Strength in Older Adults: A Population-Based Study

Miguel Germán Borda
ORCID logo ,
Jessica Samuelsson
,
Tommy Cederholm
,
Jonathan Patricio Baldera
ORCID logo ,
Mario Ulises Perez-Zepeda
ORCID logo ,
George E. Barreto
,
Anna Zettergren
,
Silke Kern
,
Rydén Lina
,
Mariana Gonzalez-Lara
ORCID logo ,
Salomón Salazar-Londoño
ORCID logo ,
Gustavo Duque
* ORCID logo ,
Ingmar Skoog
,
Dag Aarsland
Version 1 : Received: 10 January 2024 / Approved: 10 January 2024 / Online: 11 January 2024 (10:21:38 CET)

A peer-reviewed article of this Preprint also exists.

Borda, M.G.; Samuelsson, J.; Cederholm, T.; Baldera, J.P.; Pérez-Zepeda, M.U.; Barreto, G.E.; Zettergren, A.; Kern, S.; Rydén, L.; Gonzalez-Lara, M.; Salazar-Londoño, S.; Duque, G.; Skoog, I.; Aarsland, D. Nutrient Intake and Its Association with Appendicular Total Lean Mass and Muscle Function and Strength in Older Adults: A Population-Based Study. Nutrients 2024, 16, 568. Borda, M.G.; Samuelsson, J.; Cederholm, T.; Baldera, J.P.; Pérez-Zepeda, M.U.; Barreto, G.E.; Zettergren, A.; Kern, S.; Rydén, L.; Gonzalez-Lara, M.; Salazar-Londoño, S.; Duque, G.; Skoog, I.; Aarsland, D. Nutrient Intake and Its Association with Appendicular Total Lean Mass and Muscle Function and Strength in Older Adults: A Population-Based Study. Nutrients 2024, 16, 568.

Abstract

Treatment options for sarcopenia are currently limited, primarily relying on two main therapeutic approaches: resistance-based physical activity and dietary interventions. However, details about specific nutrients in the diet or supplementation are unclear. Our objective is to investigate the relationship between nutrient intake and lean mass, function, and strength. Data were derived from the Gothenburg H70 birth cohort study in Sweden, including 719 70-year-olds born in 1944 (54,1 % females). For independent variables, the diet history method (face-to-face interviews) was used to estimate habitual food intake during the preceding three months. Dependent variables were gait speed (muscle performance), hand grip strength (muscle strength) and appendicular lean soft tissue index (ALSTI). Linear regression analyses were performed to analyze the relationship between the dependent variables and each of the covariates. Several nutrients were positively associated with ALSTI, such as polyunsaturated fatty acids (DHA, EPA), selenium, zinc, riboflavin, niacin equivalent, vitamin B12, vitamin D, iron, and protein. After correction for multiple tests, there were no remaining correlations with handgrip and gait speed. Findings of positive correlations for some nutrients with lean mass suggest a role for these nutrients for maintaining muscle volume. These results can be used to inform clinical trials to expand the preventive strategies and treatment options for individuals at risk of muscle loss and sarcopenia.

Keywords

Sarcopenia; Body Composition; Aging; Diet; Walking Speed; Muscle Strength

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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