Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Musculoskeletal Pain, Physical Activity, Muscle Mass, and Mortality in the Elderly: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA)

Version 1 : Received: 10 January 2024 / Approved: 10 January 2024 / Online: 11 January 2024 (10:26:07 CET)

A peer-reviewed article of this Preprint also exists.

Hwang, S.-W.; Kim, C.-W.; Jang, Y.-J.; Lee, C.-H.; Oh, M.-K.; Kim, K.-W.; Jang, H.-C.; Lim, J.-Y.; Chun, S.-W.; Lim, S.-K. Musculoskeletal Pain, Physical Activity, Muscle Mass, and Mortality in Older Adults: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA). Medicina 2024, 60, 462. Hwang, S.-W.; Kim, C.-W.; Jang, Y.-J.; Lee, C.-H.; Oh, M.-K.; Kim, K.-W.; Jang, H.-C.; Lim, J.-Y.; Chun, S.-W.; Lim, S.-K. Musculoskeletal Pain, Physical Activity, Muscle Mass, and Mortality in Older Adults: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA). Medicina 2024, 60, 462.

Abstract

Background and objectives: Musculoskeletal (MSK) pain significantly impacts physical activity and quality of life in the elderly, potentially influencing mortality. This study explored the relationship between MSK pain, physical activity, muscle mass, and mortality among older adults. Material and Methods: We studied 1000 participants of the Korean Longitudinal Study on Health and Aging (KLoSHA), a prospective, population-based cohort study of people aged 65 years or older. Survival status was tracked over a 5-year period. Correlations between Low back pain (LBP), knee pain, regular exercise, appendicular skeletal muscle mass (ASM), and other variables were analyzed. Logistic regression analyzes were used to identify independent risk factors for mortality. Results: Of the total participants, 829 (82.9%) survived after a 5-year period. Survivors tended to be younger, had a higher BMI, and were more active in regular exercise. In contrast, non-survivors exhibited a higher prevalence of both LBP and knee pain, along with increased instances of multiple MSK pain. Lower ASM correlated moderately with LBP and knee pain, whereas higher ASM was associated with regular exercise Lower ASM was moderately associated with LBP and knee pain, while higher ASM correlated with engagement in regular exercise. There was a moderate correlation between LBP and knee pain, both of which were associated with a lack of regular exercise. Age, sex, ASM, and regular exercise were significant predictors, even though MSK pain itself did not directly predict all-cause mortality. Conclusions: This study demonstrated the independent association between ASM, regular exercise, and mortality. Although MSK pain did not directly correlate with all-cause mortality, the non-survivor group had higher levels of both single and multiple MSK pain. Recognizing the interplay of MSK pain, physical activity, and muscle mass for older adults, the research underscores the need for holistic strategies to enhance health outcomes in older individuals with MSK pain.

Keywords

Low Back Pain; Musculoskeletal pain; Exercise; Muscle, Skeletal; Mortality

Subject

Public Health and Healthcare, Physical Therapy, Sports Therapy and Rehabilitation

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