Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Bone Regeneration Therapy Using Biodegradable Scaffolds: Cal-Cium Phosphate Bioceramics and Biodegradable Polymers

Kaoru Aoki
* ,
Hirokazu Ideta
ORCID logo ,
Yukiko Komatsu
,
Atsushi Tanaka
,
Munehisa Kito
ORCID logo ,
Masanori Okamoto
ORCID logo ,
Jun Takahashi
,
Shuichiro Suzuki
,
Naoto Saito
Version 1 : Received: 10 January 2024 / Approved: 10 January 2024 / Online: 10 January 2024 (11:07:42 CET)

A peer-reviewed article of this Preprint also exists.

Aoki, K.; Ideta, H.; Komatsu, Y.; Tanaka, A.; Kito, M.; Okamoto, M.; Takahashi, J.; Suzuki, S.; Saito, N. Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers. Bioengineering 2024, 11, 180. Aoki, K.; Ideta, H.; Komatsu, Y.; Tanaka, A.; Kito, M.; Okamoto, M.; Takahashi, J.; Suzuki, S.; Saito, N. Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers. Bioengineering 2024, 11, 180.

Abstract

Synthetic bone made of calcium phosphate is widely used for the clinical treatment of bone defects caused by trauma and bone tumors. Although synthetic bone is easy to use, its effects are only partial depending on the size and location of the bone defect, and there are many treatment options other than the use of synthetic bone. Various biodegradable polymers that are being considered for use as scaffolds for regenerative medicine are also being considered for use as synthetic bones; however, commercial synthetic bone products with performance comparable to that of calcium phosphate bioceramics have not yet been clinically applied. This review introduces the practice of bone regeneration therapy with synthetic bone and recent research on bone regeneration therapy with biodegradable polymers.

Keywords

bone defect; bone regeneration; scaffold; calcium phosphate; biodegradable polymer

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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