Pazzin, D.B.; Previato, T.T.R.; Budelon Gonçalves, J.I.; Zanirati, G.; Xavier, F.A.C.; da Costa, J.C.; Marinowic, D.R. Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies. Cells2024, 13, 745.
Pazzin, D.B.; Previato, T.T.R.; Budelon Gonçalves, J.I.; Zanirati, G.; Xavier, F.A.C.; da Costa, J.C.; Marinowic, D.R. Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies. Cells 2024, 13, 745.
Pazzin, D.B.; Previato, T.T.R.; Budelon Gonçalves, J.I.; Zanirati, G.; Xavier, F.A.C.; da Costa, J.C.; Marinowic, D.R. Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies. Cells2024, 13, 745.
Pazzin, D.B.; Previato, T.T.R.; Budelon Gonçalves, J.I.; Zanirati, G.; Xavier, F.A.C.; da Costa, J.C.; Marinowic, D.R. Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies. Cells 2024, 13, 745.
Abstract
This review explores the transformative role of induced pluripotent stem cells (iPSCs) and organoids in advancing neuropathology research. Focused on Alzheimer's disease, epilepsy, Parkinson's disease, and spinal cord injury, iPSCs offer patient-specific disease modeling with regenerative therapy potential. The versatility of iPSCs, their ability to differentiate into the main neuronal cell types, and their integration into three-dimensional organoid models enable the recreation of complex tissues in vitro. Improvement of organoid and iPSCs generation protocols and the selection of appropriate donor cell types are highlighted as crucial steps toward the application of these new technologies to overcome tumorigenic potential and other challenges. iPSCs demonstrate promise in regenerative therapies, as evidenced by successful applications in animal models.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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